WGS-guided Tracking and Infection Control Measures of CRKP

Fudan University

Status: Unknown

Conditions: Klebsiella Pneumoniae Infection

Treatments: Other: screen of CRKP and infection control measure

Study type: Interventional

Funder types: Other

Identifiers

NCT04413305

KY2019-429KP

Details and patient eligibility

About

The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the hospital.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The patient was admitted to the ICU of neurosurgery in the west hospital of huashan hospital affiliated to fudan university from September 2019 to September 2021, or transferred from the ICU of another hospital
2. The patient is more than 18 years old and less than 80 years old, regardless of gender.
3. Informed consent of the patient;

Exclusion criteria

1. Patients participating in other clinical trials at the same time

2. Pregnant

3. People who will affect the outcome of the study: whose specimens could not be received or not enough for testing

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,000 participants in 2 patient groups

WGS-based screen and control group

Experimental group

Description:

For intervention group, we screen admitted patients for carbapenem-resistant Klebsiella pneumoniae and carry out 'Bundle' infection and control measures. When outbreak or tranmission of CRKP was observed, we take whole-genome sequencing to track origin and transmission route to decease CRKP rate.

Treatment:

Other: screen of CRKP and infection control measure

Non-intervention

No Intervention group

Description:

Non-intervention