WGS of NTM From Sputum of NTM Lung Disease Patients and From Their Environments (NTM_HOME)

Seoul National University

Status

Unknown

Conditions

Whole Genome Sequencing

Nontuberculous Mycobacterium Infection

Study type

Observational

Funder types

Other

Identifiers

NCT03532438

NTM_HOME

Details and patient eligibility

About

The purpose of the study is to identify the genetic closeness of NTM derived from patients living together and from their surrounding environment and to trace the temporal relationship between them.

Full description

After NTM isolation is done by using culture, from patients' sputum/bronchoscopic samples and their environmental samples, whole genome sequencing (WGS) will be conducted for all NTM isolates. Phylogenetic analysis will be performed based on single nucleotide polymorphism (SNP) on each NTM.

Enrollment

6 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The adult over 18 years of age
The patient who have respiratory symptoms consistent with NTM, such as a chronic cough, sputum, and hemoptysis, who have NTM-positive findings on CT, and who have NTM identification in two or more sputum cultures or in one or more bronchoscopic/tissue culture. (2007 ATS/IDSA guideline)
Pairs of patients living in the same household since diagnosis on NTM lung disease
Consent to a collection of environmental samples from the patient's residence.

Exclusion criteria