What is the Best Preparation for Embryo Transfer in Cryo Cycles: a Natural Cycle or Light Hormonal Stimulation?

University Hospital, Gasthuisberg

Status: Unknown

Conditions: Infertility

Treatments: Drug: human menopausal gonadotrophins

Study type: Interventional

Funder types: Other

Identifiers

NCT00492934

ML2436 - 30/12/2003

Details and patient eligibility

About

The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is higher when the cycle is started with daily, small-dose hormonal injections than in cycles without these daily injections.

Enrollment: 300 estimated patients

Sex: Female

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Signed informed consent.
• Women with a regular cycle (between 21 and 35 days).
• Embryos with 50% intact blastomeres after thawing.
• Embryo and endometrium are synchronized.

Exclusion criteria

• Embryo storage time not longer than 5 years.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 2 patient groups

1

Active Comparator group

Description:

Daily injections with a small dose of gonadotrophins from day 2 of the cycle

Treatment:

Drug: human menopausal gonadotrophins

2

No Intervention group

Description:

No daily injections with hormones