What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Murdoch Childrens Research Institute

Status: Completed

Conditions: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Invasive Pneumococcal Disease, Recurrent Isolated, 2; Invasive Pneumococcal Disease, Protection Against; Primary Immunodeficiency

Treatments: Other: Referral to Immunology

Study type: Observational

Funder types: Other

Identifiers

NCT03815357

35266C

Details and patient eligibility

About

This is a multicentre prospective audit to determine the incidence of immunodeficiency in children with IPD.

Aims and/or research question of the project

1. To determine the incidence of primary immunodeficiency in children >2 years who present with IPD
2. To determine the types of immunodeficiency associated with IPD in children

Enrollment: 380 patients

Sex: All

Ages: Under 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children aged 0 to 18 years admitted to one of the six centres with IPD.

Exclusion criteria

• Children who do not fulfil the age criteria for immunological evaluation at that particular site e.g. aged <2 years at Royal Children's Hospital.
• Children with a known underlying condition predisposing to IPD i.e. nephrotic syndrome.

Trial design

380 participants in 1 patient group

Children with IPD

Description:

Children with IPD will be referred for immunological evaluation. The protocol for immune work up will be the same but between centres there is variation in the age criteria for referral i.e. \>2 years in some, \>6 months in others.

Treatment:

Other: Referral to Immunology