Wheal and Flare Reaction During 24 Hours in Allergic Volunteers.

UCB

Status and phase

Completed

Phase 1

Conditions

Allergy

Treatments

Drug: Levocetirizine

Study type

Interventional

Funder types

Industry

Identifiers

Eudract Number: 2004-001089-41

A00373

Details and patient eligibility

About

Compare the activity of 5 mg levocetirizine and 5 mg desloratadine on allergen-induced wheal and flare reaction.

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and female allergic volunteers: Diagnosed allergy based on medical history and on positivity to skin tests to at least one of the standardized allergen including grass pollens, tree pollens, house dust mites, cat and dog dander and with a positive RAST for the specific selected allergen ≥ class 2

Exclusion criteria

Pregnancy or lactating females, or females with childbearing potential without reliable contraception
History or presence of any chronic or acute illness or disorder capable of altering the absorption, metabolism or elimination of drugs, or constituting a risk factor when taking the trial medication
Heavy caffeine drinker (> 5 cups of coffee, tea, cola, etc ... per day)
Any drug treatment, including prescribed or non-prescription medicines (except hormonal contraceptives or post-menopausal hormonal replacement therapy for females and occasional use of paracetamol not exceeding 2 g/day with a maximum dose of 10 g per 14 days), taken from 14 days before study drug administration; the wash-out period after intake of systemic corticosteroids is at least 4 weeks
Known allergy/intolerance to the study drug or any medicine chemically related to study drug or its excipients (lactose, cellulose...)
Participation in another clinical trial, blood donation or significant blood loss (> 450 mL) less than 12 weeks before the study drug administration
Skin irritant or 48 hours UV exposure before each visit
Immunotherapy received during the current year
Any clinical conditions that, in the opinion of the Investigator, would make the subject unsuitable for the trial