Whether Control of Serum Uric Acid (SUA) Improves Survival After Pancreatic Cancer

Hepatopancreatobiliary Surgery Institute of Gansu Province

Status: Enrolling

Conditions: Serum Uric Acid

Treatments: Diagnostic Test: serum uric acid test

Study type: Observational

Funder types: Other

Identifiers

NCT07091526

SUA-PC

Details and patient eligibility

About

This retrospective study aims to analyze the impact of postoperative changes in serum uric acid (SUA) levels on the prognosis of patients undergoing pancreatic cancer resection.

Full description

Serum uric acid is a risk factor for gallbladder cancer in men and has a strong effect on pancreatic cancer in women. It has also been shown that elevated intracellular serum uric acid can induce an inflammatory stress response, which may promote its transformation, while elevated extracellular serum uric acidy further stimulate tumor cell proliferation, migration, and survival, and promote the development of highly aggressive cancer. In this study, the changes of serum uric acid before and after surgery was used as a prognostic marker for the survival of pancreatic cancer patients.

Enrollment: 168 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with pathologically confirmed pancreatic cancer (primary)
• Patients who underwent Radical resection of pancreatic cancer（Pancreaticoduodenectomy or Distal pancreatectomy）
• The postoperative survival time was at least 6 weeks

Exclusion criteria

• No surgery was performed, or only palliative surgery/ biopsy was performed
• Patients who underwent emergency hemodialysis or plasma exchange after surgery
• History of gout or long-term urate-lowering therapy, such as allopurinol
• Patients are missing follow-up data
• Hydrochlorothiazide and furosemide were used
• Chronic kidney disease
• Oncolytic syndrome
• Hemolytic anemia
• Lead poisoning
• Hyperparathyroidism
• Hypothyroidism
• A tyrosinase inhibitor was used
• Patients with nonpancreatic primary tumors
• Pregnant or postpartum women.

Trial design

168 participants in 2 patient groups

High serum uric acid

Description:

The increase of after serum uric acid operation compared with that before operation is≥10% Normal levels serum uric acid are typically 178 to 360 μm (3 to 6.8 mg/dl).

Treatment:

Diagnostic Test: serum uric acid test

Low serum uric acid

Description:

The increase of after serum uric acid operation compared with that before operation \< 10% Normal serum uric acid levels are typically 178 to 360 μm (3 to 6.8 mg/dl).

Treatment:

Diagnostic Test: serum uric acid test