Whey Protein, Resistance Training, and Changes in Body Composition

Kansas Board of Regents

Status: Completed

Conditions: Obesity

Treatments: Dietary Supplement: Soy Protein Supplement; Dietary Supplement: Carbohydrate supplement; Dietary Supplement: Whey Protein supplement

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01186536

DMI01425 (Other Grant/Funding Number)

HSCL16583

Details and patient eligibility

About

The objective of this project is to determine the effect of 9 months of progressive resistance training with daily whey protein supplements on the body composition (changes in muscle and fat) in young adults. The investigators hypothesize that those individuals who receive whey protein supplements will have larger gains in muscle and larger losses of fat tissue in response to resistance training compared to those who receive supplements of soy or carbohydrate.

Full description

Healthy men and women will be recruited to participate in 9 months of supervised resistance training (3 days/wk) and will be randomized to one of three daily supplement groups: Whey protein, soy protein, or carbohydrate control. Body weight, muscular strength and endurance, and resting blood pressure will be assessed at baseline, 3, 6 and 9 months. Body composition will be assessed at baseline, 3, 5, 7, and 9 months. A sub-sample (N = 17 per group, assessed at baseline and 9 months) will be randomly selected for muscle samples of the upper leg to determine changes in the size of muscle fibers, and chemical factors associated with muscle growth. Blood samples will be obtained from sub-sample participants to assess changes in glucose and fat metabolism, as well as other chemicals likely to promote or inhibit muscle growth. We will also assess changes in daily energy expenditure and the use of fuel to produce energy (carbohydrate, fat, protein) that may result from the intervention. We hypothesize that those individuals who receive whey protein supplements will have larger gains in muscle and larger losses of fat tissue in response to resistance training compared to those who receive supplements of soy or carbohydrate.

Enrollment: 85 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 25-39.9
• must be 18- 30 years old
• sedentary
• no medications
• stable weight for at least 3 months

Exclusion criteria

• Tobacco/Drug user
• metabolism altering medication
• gain/lost 10lbs in the last 3 months
• current exerciser

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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85 participants in 3 patient groups

Whey protein supplementation

Experimental group

Description:

Daily whey protein supplementation

Treatment:

Dietary Supplement: Whey Protein supplement

Soy Protein supplementation

Experimental group

Description:

Daily soy protein supplementation

Treatment:

Dietary Supplement: Soy Protein Supplement

Placebo

Experimental group

Description:

Daily carbohydrate placebo supplementation

Treatment:

Dietary Supplement: Carbohydrate supplement