White Blood Cell SPECT/CT and Diabetic Foot Osteomyelitis

Civil Hospices of Lyon

Status: Unknown

Conditions: Diabetic Foot Osteomyelitis

Treatments: Other: white blood cell SPECT/CT (Single Photon Emission Computed Tomography/Computed Tomography) imaging

Study type: Observational

Funder types: Other

Identifiers

NCT02927678

69HCL16_0597

Details and patient eligibility

About

Osteomyelitis is a risk factor for lower extremity amputation in diabetic people. Antibiotic therapy allows a remission in 60 to 80% of cases. However the optimal duration of antibiotic therapy remains controversy due to the absence of validated marker of osteomyelitis remission. We have previously shown that the negativity of white blood cell SPECT/CT (Single Photon Emission Computed Tomography/Computed Tomography) imaging at the end of treatment allowed to predict remission of osteomyelitis at 1 year in all cases. A positive imaging was associated with recurrence in 70% of cases. The aim of our study was to evaluate prospectively the interest of white blood cell SPECT/CT to set the duration of antibiotic therapy.

Enrollment: 56 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years
• Diabetes
• Osteomyelitis defined by soft tissue infection and/or positive probe-to-bone test and suggestive signs of osteomyelitis on plain-X-Ray

Exclusion criteria

• Indication for acute surgical bone resection or amputation

Trial design

56 participants in 1 patient group

Diabetic patients with osteomyelitis

Description:

Patients with a clinical and radiological diagnosis of osteomyelitis were included in two diabetic centers

Treatment:

Other: white blood cell SPECT/CT (Single Photon Emission Computed Tomography/Computed Tomography) imaging