White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study

San Donato Group (GSD)

Status

Completed

Conditions

White Matter Hyperintensities

Congenital Heart Disease

Aging, Premature

Treatments

Other: Neuropsychological test battery

Other: Brain MRI

Study type

Observational

Funder types

Other

Identifiers

NCT03487302

LEUCO

Details and patient eligibility

About

The study aims at investigating the role of cyanotic congenital heart disease (cCHD) on brain aging. The investigators assume that due to congenital and acquired cardiovascular abnormalities, cCHD patients could show radiologic (and clinical) signs of precocious brain aging and eventual cognitive decline.

Full description

White matter hyperintensities burden will be quantified through a semi-autamated software (ITK-SNAP)

Enrollment

146 patients

Sex

All

Ages

20+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

for the patient group, being an adult subject affected with cyanotic congenital heart disease, whether surgically corrected or not.
for the control group, being an healthy subject.

Exclusion criteria

any contraindication to magnetic resonance imaging;
any pathological condition and/or symptomp that could alter the white matter hyperintensities burden, among which:
- inflammatory, infectious, demyelinating or dysmyelinating diseases of the CNS;
- ischemic, haemorrhagic or traumatic brain events and eventual gliotic and malacic or lacunar sequelae;
- genetic diseases (whether mendelian or mitochondrial) of the CNS;
- cerebral amyloid angiopathy;
- CADASIL;
- cerebral arteriovenous malformations;
- primary or metastatic brain neoplasms which cause neurological symptoms and/or brain parenchymal sequelae from surgical excision;
- patent oval foramen;
- being pregnant;
- migraine with aura (Bashir, Lipton, Ashina, & Ashina, 2013).