Whole Blood Biospecimen Collection for Subjects With Chronic Granulomatous Disease (CGD)

Sanguine Biosciences

Status: Terminated

Conditions: Chronic Granulomatous Disease

Treatments: Diagnostic Test: Specimen Donation

Study type: Observational

Funder types: Industry

Identifiers

NCT05915897

SAN-09687

Details and patient eligibility

About

The primary study objective is to collect biospecimen samples (e.g., blood) from participants diagnosed with Chronic Granulomatous Disease (CGD). The biospecimens will be used to create a biorepository that can be used to identify disease associated biomarkers and potential targets with immune and multi-omics profiling. The disease sample collection and analysis will be the foundation for an extensive network of biospecimen access and linked datasets for future translational research.

Enrollment: 6 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The participant is willing and able to provide written informed consent
• The participant is willing and able to provide appropriate photo identification
• Participants aged 18 to 85
• Participants have been diagnosed with Chronic Granulomatous Disease (CGD)
• Subjects who have a confirmed p47phox CGD mutation or Subjects who have a confirmed X-linked CGD mutation

Exclusion criteria

• Participants who are pregnant or are nursing
• Participants with a known history of HIV, hepatitis, or other infectious diseases
• Participants who have taken an investigational product in the last 30 days
• Participants who have experienced excess blood loss, including blood donation, defined as 250 mL in the last month or 500 mL in the previous two months

Trial design

6 participants in 2 patient groups

CGD with p47phox phenotype

Treatment:

Diagnostic Test: Specimen Donation

X-Linked CGD

Treatment:

Diagnostic Test: Specimen Donation