Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis (NEFIMAR)

Universitaire Ziekenhuizen KU Leuven

Status: Unknown

Conditions: Peripheral Nerve Sheath Tumors, Malignant; Neurofibromatosis 1; Whole Body Imaging; Diffusion Magnetic Resonance Imaging; Magnetic Resonance Imaging

Treatments: Other: Additional imaging or surgery

Study type: Observational

Funder types: Other

Identifiers

NCT01777451

S52684 (Other Identifier)

NEFIMAR

Details and patient eligibility

About

Whole body MRI will be performed in patients with neurofibromatosis Type 1

PURPOSE 1:

To determine the total tumor load (neurofibroma) and to diagnose plexiform neurofibromas or malignant peripheral nerve sheath tumors. All patients will be scanned two years after the baseline whole body MRI to investigate to investigate the changes of total tumor load.

PURPOSE 2: added value of diffusion weighted imaging in diagnosis of high-risk neurofibromas

PURPOSE 3 : to determine the apparent diffusion coefficient of the malignant nerve sheath tumors and neurofibroma.

PURPOSE 4 : correlation between histopathology of the surgically resected neurofibroma/malignant nerve sheath tumors and MRI findings

Enrollment: 30 estimated patients

Sex: All

Ages: 6 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with neurofibromatosis type 1, between 6 and 50 years old

Exclusion criteria

• Patients who are not allowed to be scanned on MRI (contra-indications: pacemaker ed.)

Trial design

30 participants in 1 patient group

Neurofibromatosis 1

Description:

All patients diagnosed with neurofibromatosis type 1. GROUP 1:ADDITIONAL IMAGING OR SURGERY There will be patients with high-risk neurofibromas (potential malignant). These patients will underwent additional examinations or surgery (outside this study). Follow-up MRI within 2 years (study MRI ) GROUP 2: No suspicious lesions at MRI. Follow-up within 2 years(Study MRI).

Treatment:

Other: Additional imaging or surgery