Whole Body Protein Metabolism of a Whey/EAA Supplement Using Continuous Oral Stable Isotopes

University of Arkansas

Status: Completed

Conditions: Healthy

Treatments: Other: Oral amino acid tracer

Study type: Interventional

Funder types: Other

Identifiers

NCT04612400

260813

Details and patient eligibility

About

To evaluate the validity of a continuous oral sip-feeding method of stable isotope tracer for the evaluation of whole-body protein metabolism in response to two different doses of an EAA/whey protein supplement (Low=6.3g and High=12.6g). Results will be compared to those previously determined by constant infusion with the same EAA/whey supplement.

Full description

This will be a double-blinded, randomized, crossover pilot study to evaluate the validity of a continuous oral sip-feeding of stable isotope tracer method for the evaluation of whole-body protein metabolism. This method will be evaluated using two different amounts of an essential amino acid (EAA) + whey protein supplement on up to six younger, healthy subjects. Stable isotope preparations will be continuously consumed by subjects throughout visits 2 and 3 to enable whole body protein metabolism to be measured.

Enrollment: 8 patients

Sex: All

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 21-40 years.
• Body weight of ≤ 80kg.

Exclusion criteria

• History Chronic kidney disease.
• History of dairy allergy or intolerance.
• History of gastric reduction/bypass surgery.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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8 participants in 2 patient groups

Low

Experimental group

Description:

Low dose (6.3g) EAA/whey protein supplement

Treatment:

Other: Oral amino acid tracer

High

Experimental group

Description:

High dose (12.6g) EAA/whey protein supplement

Treatment:

Other: Oral amino acid tracer