Whole Body Vibration and the Brain in OSA

University of California, Los Angeles (UCLA)

Status

Withdrawn

Conditions

Obstructive Sleep Apnea

Treatments

Device: Whole Body Vibration

Study type

Interventional

Funder types

Other

Identifiers

NCT04009486

19-006112

Details and patient eligibility

About

Participants will have an overnight polysomnography (recording apnea-hypopnea index), MRI (brain structure), and a sleep symptoms questionnaire for baseline data. Participants will then undergo 6 weeks of whole body vibration (using the whole body vibration device), 3 times a week for 30 minutes sessions. After 6 weeks, participants will have complete another polysomnography, MRI and sleep questionnaire.

Full description

OSA subjects will be recruited from the UCLA Sleep Disorders Center via recruitment flyers. When prospective subjects contact the study coordinator, the study will be explained in greater detail, and inclusion and exclusion criteria reviewed. If the person agrees to participate, appointments for data collection will be made and copies of the informed consent will be mailed for their review for at least 3 days before the study. Then the Project Coordinator or one of the PI's will contact the prospective subject, answer any questions about the study, and obtain signed, informed consent. Baseline measures (PSQI, BDI-II, height, weight, vital signs [temperature, heart rate, blood pressure]) will be obtained. At 6 weeks, baseline measures will be repeated and an overnight polysomnography study will be performed at the subject's home. All subjects will be given the WBV device at the end of the study. Delivery of the WBV device to each subject's home will be arranged and the WBV device and pedometer set up by the research team. Training in the use of the WBV device will be provided inperson and via written instructions. Phone and e-mail support for the WBV device or any study questions will be available for all study participants. Subjects will use the device at least 3 times/week, for 30 minutes per session, for 6 weeks. In addition to the pedometer, a wall calendar will be provided on which subjects will mark the days that they use the WBV device. Project Coordinator will visit subjects weekly, and as needed, to record pedometer readings, check wall calendar for WBV device use, and to answer any subjects' questions or concerns. Brain MRI scans will be performed at baseline and after 6 weeks. An MRI-compatible pulse oximeter, and an air-filled pressure transducer will be connected to the subject to monitor heart rate, O2 saturation, and thoracic wall movement, and then the subject will be positioned in the scanner for data collection.

Sex

All

Ages

40 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

AHI ≥15
new diagnosis of moderate to severe OSA (via overnight polysomnography)
and able to lay flat (requirement for brain MRI)
must have space and electrical power access for WBV device at their home

Exclusion criteria

other forms of sleep-disordered breathing (such as central sleep apnea, restless legs syndrome, mixed sleep apnea)
currently using (or will start using during 6-week study period) CPAP or BiPAP or oral appliance for OSA treatment
recent (<6 months) myocardial infarction
current pregnancy (if subject is female)
history of stroke
diagnosed psychiatric disease (schizophrenia, manic-depressive)
airway or chest deformities that would interfere with breathing
mechanical ventilatory support
renal failure (requiring dialysis)

For brain MRI

claustrophobia
metallic-based tattoos
metallic implants or devices (such as implantable cardioverter-defibrillator, pacemaker, embolic coils, aneurysm clips) or any other material that could be hazardous in MRI scanner
body weight >300 lbs (restrictions of MRI scanner table)