Whole Egg Intake and Choline Concentration in the Aging Brain

University of Kansas

Status

Completed

Conditions

Alzheimer Disease

Study type

Observational

Funder types

Other

Identifiers

NCT05021211

STUDY00146588

Details and patient eligibility

About

By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition.

Full description

Participants will come to the research center for 2 different visits. Visit 1 will include anthropometric measurements, surveys, and a cognitive test. Approximately 7-10 days after visit 1, participants will come back to the research center for visit 2. At visit 2, participants will return surveys and a MRI scan will be performed to measure brain choline status. Potential participants need to be located within the Kansas City metro area.

Enrollment

60 patients

Sex

All

Ages

60 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged between 60 - 85 years of age
Good general health with no concomitant diseases
Cognitively normal as defined as Mini-mental state examination (MMSE) score ≥ 25
BMI range: 20 - 40 kg/m2

Exclusion criteria

Presence of central neurological disease (e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer's, Parkinson's)
Prior major head trauma with loss of consciousness
Presence of active unstable and life-threatening illness (e.g., cancer)
Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score > 6)
Presence of diabetes mellitus or use of anti-diabetic agents
Use of psychoactive and investigational medications
Use of hormone replacement therapy
Tobacco smokers
Subjects with MRI contraindications