Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

National Cancer Institute (NCI)

Status: Enrolling

Conditions: Breast Carcinoma

Treatments: Other: Laboratory Biomarker Analysis

Study type: Observational

Funder types: NIH

Identifiers

NCT02610426

U10CA180820 (U.S. NIH Grant/Contract)

ECOG-E5103T3

NCI-2013-02291 (Registry Identifier)

E5103T3 (Other Identifier)

Details and patient eligibility

About

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with congestive heart failure receiving therapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with congestive heart failure receiving therapy for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to congestive heart failure.

Full description

PRIMARY OBJECTIVES:

I. To identify, using next generation sequencing, rare variants of large effect size that impact the risk of congestive heart failure (CHF) in patients from the clinical trial ECOG-5103 (E5103).

OUTLINE:

Previously collected germline DNA samples are analyzed via whole exome sequencing.

Enrollment: 162 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• European American patients with DNA available
• European American patients who developed CHF and patients who did not develop CHF following a full course of treatment with an anthracycline and bevacizumab
• African American cases (based on a drop in left ventricular ejection fraction [LVEF] < 50 or a drop from baseline > 20 points) and African American controls

Trial design

162 participants in 1 patient group

Ancillary-Correlative (whole exome sequencing)

Description:

Previously collected germline DNA samples are analyzed via whole exome sequencing.

Treatment:

Other: Laboratory Biomarker Analysis