Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

National Cancer Institute (NCI) logo

National Cancer Institute (NCI)

Status

Enrolling

Conditions

Breast Carcinoma

Treatments

Other: Laboratory Biomarker Analysis

Study type

Observational

Funder types

NIH

Identifiers

NCT02610413
U10CA180820 (U.S. NIH Grant/Contract)
ECOG-E5103T2
NCI-2013-02289 (Registry Identifier)
E5103T2 (Other Identifier)

Details and patient eligibility

About

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with hypertension receiving bevacizumab for breast cancer. Studying samples of germline DNA in the laboratory from patients with hypertension receiving bevacizumab for breast cancer may help doctors learn about changes that occur in DNA and identify biomarkers related to hypertension.

Full description

PRIMARY OBJECTIVES: I. To identify, using next generation sequencing, rare variants of large effect size that impact the risk of hypertension in patients from the clinical trial Eastern Cooperative Oncology Group (ECOG)-5103 (E5103). OUTLINE: Previously collected germline DNA samples are analyzed via whole exome sequencing.

Enrollment

354 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • European American patients with deoxyribonucleic acid (DNA) available and designated case or control
  • Patients who developed grade 3-4 bevacizumab-induced hypertension during their treatment with bevacizumab
  • Patients who did not develop hypertension following a full course of treatment with bevacizumab

Trial design

354 participants in 1 patient group

Ancillary-Correlative (whole exome sequencing)
Description:
Previously collected germline DNA samples are analyzed via whole exome sequencing.
Treatment:
Other: Laboratory Biomarker Analysis

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems