Wholebody MRI In Lung Cancer StagiNg (WISLON)

University of Limoges (UL)

Status: Completed

Conditions: Lung Cancer

Treatments: Device: PET; Device: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02716051

I15037/WILSON

Details and patient eligibility

About

Magnetic Resonnace Imaging (MRI) and Positron Emission Tomography (PET) can be both used in detection of nodes in patients with cell lung cancer (NSCLC).

However, the cardiorespiratory synchronization in the MRI, allowing acquisition of synchronous images with breathing and heart movements should increase the sensitivity of detection of pathologic mediastinal lymph nodes.

Given its high sensitivity, whole-body MRI with diffusion could possibly be at least as informative as PET, while being less expensive, not radiant.

The purpose of this study is to evaluate the performance of whole-body MRI with diffusion with cardiorespiratory synchronization, on the detection of mediastinal nodes (which are known to be less well detected by MRI) compared to PET.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• At least 18 years,
• Neoplasia bronchopulmonary (SCLC and NSCLC) newly diagnosed,
• Patient potentially eligible for curative treatment, but no no treatment started,
• Patients for whom a PET scan and MRI are planned

Non Inclusion Criteria:

• claustrophobia,
• Implantable Medical Device
• not compatible pacemaker type or heart valve, metal splinters eye)
• Pregnant or lactating women,

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

MRI

Experimental group

Description:

Wholebody MRI with cardio-pulmonary synchronization At day 1 , at the afternoon, patient will undergo an MRI analysis.

Treatment:

Device: MRI

PET

Active Comparator group

Description:

At day 1 , in the morning, patient will undergo an PET analysis

Treatment:

Device: PET