Will Erectile Dysfunction Increase the Risk of Prostate Cancer (EDtoPC)

Kuang Tien General Hospital

Status: Completed

Conditions: Erectile Dysfunction

Treatments: Other: Erectile dysfunction

Study type: Observational

Funder types: Other

Identifiers

NCT03009123

KTGH-ASIAU-obs-erectile

Details and patient eligibility

About

The rationale for investigating the hypothesis that there is an association between erectile dysfunction (ED) and the subsequent development of prostate cancer is based on three assumptions: 1) baseline ED is common in most if not all of the cross-sectional studies in men with prostate cancer; 2) the development of ED and prostate cancer may have certain shared common risk factors; and 3) the use of testosterone for the treatment of ED has been suspected to be associated with prostate cancer development. Controversy exists over whether men with ED have an increased risk of subsequent prostate cancer. Few studies have evaluated the risk of developing prostate cancer for men with ED. The investigators, therefore, conducted a population-based longitudinal study with eight years' follow-up to examine this association and to evaluate the magnitude of the risk.

Enrollment: 21,558 patients

Sex: Male

Ages: 50 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• men 50 years and older with no pre-existing prostate cancer

Exclusion criteria

• less than 50 years old
• pre-existing prostate cancer

Trial design

21,558 participants in 3 patient groups

Erectile dysfunction group

Description:

Group contains men with physician-diagnosed erectile dysfunction

Treatment:

Other: Erectile dysfunction

General population men without ED

Description:

Men 50 years and older having no ED and pre-existing prostate cancer

Symptomatic BPH group without ED

Description:

Men 50 years old older with symptomatic prostatic hypertrophy but with no ED nor pre-existing prostate cancer