Woodsmoke Exposure and Cardiovascular Function

University of Edinburgh

Status: Completed

Conditions: Systemic Inflammation; Respiratory Inflammation

Treatments: Other: Bronchoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT01488500

WOODSMOKE II

Details and patient eligibility

About

Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract. It is not determined how different types of biomass combustion affect human health. In this study the investigators plan to investigate how inhalation of wood smoke and pellets smoke affect respiratory and cardiovascular health.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Use of regular medication except the oral contraceptive pill
• Current smokers
• Significant occupation exposure to air pollution
• Intercurrent illness

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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20 participants in 3 patient groups

Filtered air exposure

Experimental group

Description:

3 hour exposure to filtered air with intermittent exercise

Treatment:

Other: Bronchoscopy

Wood smoke exposure

Experimental group

Description:

3 hour exposure to dilute wood smoke generated from incomplete combustion in a wood burning stove at approximately 300 mcg/m3

Treatment:

Other: Bronchoscopy

Wood pellet smoke emission

Experimental group

Description:

3 hour exposure to dilute wood smoke generated from wood pellets during incomplete combustion during intermittent exercise at approximately 300 mcg/m3

Treatment:

Other: Bronchoscopy