Words Generation in Compulsives Gamblers and Parkinson's Disease Patients (FLUENCE)

Toulouse University Hospital

Status

Completed

Conditions

Parkinson Disease

Treatments

Other: evaluation of word generation and of motivation

Study type

Interventional

Funder types

Other

Identifiers

NCT01888276

11 225 02

Details and patient eligibility

About

The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.

Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.

Full description

The main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of PD patients with and without hyper-dopaminergic behaviors collected during another study.

2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers

Each subject will realize twice each test during 2 sessions with one hour in between :

During the session 1 :

The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs. The test of Stroop that assesses selective attention

During the session 2:

The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs. The task of the casino (Iowa Gambling Test) The task of landing The test of Stroop

We supposed that the performance of compulsive gamblers in words generation test will be higher than those of healthy volunteers, themselves superior to those of PD patients with a hyper-dopaminergic behavior, themselves superior to those of PD patient without hyper-dopaminergic behavior.

Enrollment

37 patients

Sex

All

Ages

30 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For healthy volunteers :

Subject from 30 to 75 years old (Male and female)
Subject with French mother tongue
Subject who give their informed and signed consent.
Subject affiliated to a social protection program

For compulsive gamblers :

Subject from 30 to 75 years old (Male and female)
Subject with French mother tongue
Subject with at least 5 criteria of 10 DSM IV diagnostic criteria for pathological gambling
Subject who give their informed and signed consent.
Subject affiliated to a social protection program

Exclusion criteria

For healthy volunteers and compulsive gamblers :

Presence of apathy defined as a score greater or equal to 14 on the scale of Starkstein
Presence of severe depression defined as a score greater or equal to 25 on the scale BDI (Beck Depression Inventory)
Presence of dementia defined as a score below 25 on the MMSE
Subject with vision problems making it impossible for the tests
Pregnant women
Subject under tutelage, curatelle or law protection
Subject included in an other clinical study