Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

Czech Technical University in Prague

Status: Active, not recruiting

Conditions: Accident Caused by Snow Avalanche

Treatments: Other: extreme hypercapnia induced by ventilation insufficiency

Study type: Interventional

Funder types: Other

Identifiers

NCT04835545

DP-2021-Nemec

Details and patient eligibility

About

The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.

Full description

The study is a part of a university diploma thesis aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. The Investigator is measuring Work of Breathing in three scenarios: a) 2L air pocket, b) 2L air pocket with resistance compensation and c) no air pocket. The investigator hypothesize that the Work of Breathing during compensation of air pocket will be alike with no air pocket scenario, thus proving significance of the resistance reduction for survival. The aim of the study is to investigate the effect of Work of Breathing on gas exchange in subjects breathing into the simulated avalanche snow scenarios.

Enrollment: 13 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
• without a smoking history

Exclusion criteria

• Tiffeneau Index less than 0.70
• any cardiovascular or respiratory condition

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

13 participants in 3 patient groups

Wet Perlite, 2L air pocket

Experimental group

Description:

Breathing in the simulated avalanche snow. Breathing into model of wet perlite with 2L air pocket

Treatment:

Other: extreme hypercapnia induced by ventilation insufficiency

Wet Perlite 2L air pocket with resistance compensation

Experimental group

Description:

Breathing in the simulated avalanche snow. Breathing into model of wet perlite 2L air pocket with resistance compensation

Treatment:

Other: extreme hypercapnia induced by ventilation insufficiency

Wet Perlite, no air pocket

Experimental group

Description:

Breathing in the simulated avalanche snow. Breathing into model of wet perlite with no air pocket

Treatment:

Other: extreme hypercapnia induced by ventilation insufficiency