World Health Organization (WHO) , COVID19 Case Series of Post Covid 19 Rhino Orbito Cerebral Mucormycosis in Egypt

Nasser Institute For Research and Treatment

Status and phase: Completed; Phase 2; Phase 1

Conditions: COVID-19; Mucormycosis; Rhinocerebral (Etiology)

Treatments: Procedure: debridment

Study type: Interventional

Funder types: Other

Identifiers

NCT06267326

Nasser institute

Details and patient eligibility

About

Objectives: identify and recognize clinical Characteristics, Pathophysiology, and management of a group of patients with rhino Rhino-Orbito-Cerebral Mucormycosis infection associated with Covid 19 viral infection

Enrollment: 35 patients

Sex: All

Ages: 22 to 77 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all patients with mucormycosis post covid 19

Exclusion criteria

• The patient not suffered from covid 19

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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35 participants in 2 patient groups

Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17 years

Other group

Description:

Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17 years eighteen patients presented with COVID 19 and seventeen patients presented to our hospital post healing with history of using large doses of systemic corticosteroids. patients were managed by aggressive surgical debridement, antifungal drugs Amphotericin B and adjunctive treatment like local irrigation with amphotericin B and hyperbaric oxygen according to systemic conditions of patients. Hyperbaric oxygen was used in five patients post-surgically. all investigations were done with mean values of blood glucose level, hemoglobin and WBC were noticeably abnormal. The degree of severity, length of stay, and mortality rate were significantly correlated with the severity of systemic predisposing factors

Treatment:

Procedure: debridment

Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17

Experimental group

Description:

Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17 years eighteen patients presented with COVID 19 and seventeen patients presented to our hospital post healing with history of using large doses of systemic corticosteroids. patients were managed by aggressive surgical debridement, antifungal drugs Amphotericin B and adjunctive treatment like local irrigation with amphotericin B and hyperbaric oxygen according to systemic conditions of patients. Hyperbaric oxygen was used in five patients post-surgically. all investigations were done with mean values of blood glucose level, hemoglobin and WBC were noticeably abnormal. The degree of severity, length of stay, and mortality rate were significantly correlated with the severity of systemic predisposing factors

Treatment:

Procedure: debridment