Status
Conditions
Treatments
About
Quest for modifier genes associated with ventricular arrhythmias in presence of a cardiac sodium channel gene (SCN5A-delPhe1617) mutation.
Full description
In a large Dutch SCN5A founder population with malignant ventricular arrhythmias, the investigators aim to identify genetic modifiers by means of whole-exome sequencing and to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular electrophysiological characteristics and neurocardiac modulation.
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
Inclusion Criteria (mutation carrier group):
Inclusion Criteria (non-mutation carrier group):
Inclusion criteria Spouse Group
Exclusion Criteria:
Primary purpose
Allocation
Interventional model
Masking
223 participants in 3 patient groups, including a placebo group
Loading...
Central trial contact
Paul Volders, M.D., Ph.D.; Rachel ter Bekke, M.D.
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal