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Wound Healing In Diabetes (WHy) Study

T

The University of The West Indies

Status

Unknown

Conditions

Diabetes Mellitus
Impaired Wound Healing

Study type

Observational

Funder types

Other

Identifiers

NCT01002521
CDRC-WHy-1

Details and patient eligibility

About

This observational study aims to identify risk factors and molecular mechanisms of impaired wound healing, to guide better foot care in the diabetic population.

Full description

Diabetes is linked with vascular complications of the eye, kidney and foot. Barbadians suffer from an unusually high prevalence of diabetic foot complications, which can cause difficult-to-heal foot ulcers and even lead to amputations of the toes or feet.Studies from the CDRC have indicated alarmingly high rates of amputation and mortality due to diabetic foot in Barbados. The goal of this study is to improve early detection of persons at risk of the vascular complications of diabetes through non-invasive scanning and genetic susceptibility tests.

The general hypothesis to be tested in this study is that persons with diabetes (PWD) and non-healing foot ulcers are more likely to have a disturbed mechanism for wound-healing than PWD without this particular complication. If the hypothesis is proven correct, this will empower patients and physicians with the diagnostic tests to make early interventions towards avoiding the complications of diabetes.

Enrollment

605 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • clinical diagnosis of diabetes
  • Barbadian national
  • self reported ethnicity of Black/African descent
  • clear knowledge of ulcer history

Exclusion criteria

  • no clinical diagnosis of diabetes
  • non-national of Barbados
  • self reported ethnicity not Black/African Descent
  • unclear knowledge of ulcer history

Trial design

605 participants in 2 patient groups

Cases
Description:
Persons With Diabetes (PWD) who have current non-healing ulcer(s)
Controls
Description:
Persons With Diabetes (PWD) with no current ulcers and no history of ulcers

Trial contacts and locations

1

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Central trial contact

Andre R Greenidge, BSc; Robert C Landis, PhD

Data sourced from clinicaltrials.gov

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