Wound Vitality Markers in Forensic Pathology (PLAIES VITALES)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Wound

Treatments: Other: Abdominoplasty with exeresis of cutaneous tissue; Other: Collection of cutaneous tissue

Study type: Observational

Funder types: Other

Identifiers

NCT02892526

2012/CPRC/PLAIES VITALES/MART

Details and patient eligibility

About

The purpose is to determine intrinsic properties of various immunohistochemical markers (FVIIIra, CD15, CD30, tryptase, TNFα, IL-1β, TGFα et TGFβ1) for diagnosis of vital wound, alone and in association (evaluation of sensibility with surgery wounds and evaluation of specificity with post-mortem wounds).

Secondary purposes are to measure the minimum time to obtain a positive labeling in vital wounds, and to evaluate inter-observer reproducibility of vitality diagnosis with different markers. Expression of microRNA miR 9, miR 21 et miR 198 will be also studied.

Enrollment: 57 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Alive persons:

• Abdominoplasty

Deceased persons:

• Medico-scientific autopsy for diagnosis

Exclusion criteria

Alive persons:

• Fragmented sample with non-visible banks
• Cutaneous pathology

Deceased persons:

• Persons under protection
• Medico-legal obstacle
• Cutaneous pathology

Trial design

57 participants in 2 patient groups

Vital wounds

Description:

from abdominoplasty of alive persons

Treatment:

Other: Abdominoplasty with exeresis of cutaneous tissue

Post-mortem wounds

Description:

from autopsy of deceased persons

Treatment:

Other: Collection of cutaneous tissue