Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study

Sheba Medical Center

Status: Unknown

Conditions: Osteoarthritis

Study type: Observational

Funder types: Other

Identifiers

NCT00669201

SHEBA-08-4912-IE-CTIL

Details and patient eligibility

About

Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage.

Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist.

MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Phase 1. Age:18-40
• Phase 2: No age limit, known OA on pre-existing X-rays
• Phase 3: No age limit, routine MRI of the wrist

Exclusion criteria

• Phase 1, 2: wrist trauma/surgery
• All phases: any contraindication for MR: eg metals, claustrophobia, etc.

Trial design

70 participants in 3 patient groups

1

Description:

healthy young volunteers Inclusion: age 18-40, Exclusion: wrist trauma/surgery

2

Description:

patients with know osteoarthritis wrist changes according to pre-existing x-rays No age limits exclusion: previous wrist surgery

3

Description:

Mixed group of 50 patients that perform routine MRI of the wrist for various indications