Xanthine Oxidase and Uric Acid Origin in Preeclamptic Women

Barzilai Medical Center

Status: Enrolling

Conditions: Pre-Eclampsia; Hyperuricemia

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04463940

0024-19-BRZ

Details and patient eligibility

About

Findings regarding the presence of xanthine oxidase and uric acid in different blood locations is important in preeclamptic women. We aim to detecting Xanthine oxidase and uric acid levels in both umbilical cord artery and vein as well as maternal blood (3 "locations") in pregnant women with and without diagnosis of preeclampsia. The study population will be divided into groups matching the three "locations" in order to describe and compare outcome levels.

Full description

Significance - findings regarding the presence of xanthine oxidase and uric acid in different blood locations may provide a scientific basis for understanding the source of them in preeclamptic women. Aim - detecting Xanthine oxidase and uric acid levels in both umbilical cord artery and vein as well as maternal blood (3 "locations"). Methods - samples will be collected from pregnant women with and without diagnosis of preeclampsia with blood uric acid > 6 mg/dL. Than the study population will be divided into groups matching the three "locations". The investigators will describe and compare outcome levels (including Xanthine oxidase, uric acid).

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• preeclampsia and none-preeclampsia diagnosed pregnant women.

Exclusion criteria

• Known or reported kidney disease.

Trial design

100 participants in 3 patient groups

Umbilical cord arterial blood

Description:

participant's umbilical cord arterial blood will be obtained

Treatment:

Other: No intervention

Umbilical cord venus blood

Description:

participant's umbilical cord Venus blood will be obtained

Treatment:

Other: No intervention

Maternal blood

Description:

participant's blood will be obtained

Treatment:

Other: No intervention