Xenograft with or Without Erythropoietin in Immediate Dental Implant

Cairo University (CU)

Status: Not yet enrolling

Conditions: Hopeless Teeth

Treatments: Combination Product: Erythropoietin (EPO) with xenograft; Other: Xenograft alone

Study type: Interventional

Funder types: Other

Identifiers

NCT06601400

Erythropoietin,Dental implant

Details and patient eligibility

About

The aim of this study is to evaluate changes in buccal bone thickness after immediate implant placement with xenograft mixed with erythropoietin in the anterior maxilla with a thin buccal bone

Full description

PICO:

Population: Patients with non-restorable tooth in anterior maxilla with thin buccal bone (less than 1mm) Intervention: Immediate implant placement with Xenograft mixed with Erythropoietin.

Control: Immediate implant placement with Xenograft alone.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion criteria

  • Adult (≥18 years) with non-restorable maxillary teeth in the esthetic zone (upper right second premolar to upper left second premolar).
  • Intact with thin labial plate of bone (≤1mm).
  • The recipient site of the implant should be free from any pathological conditions.
  • Patients who are cooperative, motivated and hygiene conscious.
  • Appropriate crown height space to maintain favorable crown : implant ratio

• Exclusion criteria

  • Systemic conditions/diseases that contraindicate surgery.
  • Patients who have any habits that might jeopardize the osseointegration process, such as current smokers.
  • Patients with parafunctional habits that produce overload on implant, such as bruxism and clenching.
  • Patients with periodontal disease.
  • Alcohol or drug abuse.
  • Pregnant and lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Group A (Test)

Experimental group

Description:

Immediate implant placement with Xenograft mixed with Erythropoietin

Treatment:

Combination Product: Erythropoietin (EPO) with xenograft

Group B (Control)

Active Comparator group

Description:

Immediate implant placement with Xenograft alone

Treatment:

Other: Xenograft alone