ClinicalTrials.Veeva

Menu

Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.

U

Universitaire Ziekenhuizen KU Leuven

Status and phase

Completed
Phase 2

Conditions

Coronary Artery Disease
Anesthesia

Treatments

Drug: propofol
Drug: Xenon and propofol

Study type

Interventional

Funder types

Other

Identifiers

NCT01948765
SR022013

Details and patient eligibility

About

The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic stability.

Enrollment

50 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients with coronary artery disease scheduled for elective OPCAB-surgery
  • patients willing and able to complete the requirements of this study
  • Ejection fraction >30%

Exclusion criteria

  • Lack of informed consent
  • age < 18 years
  • COPD GOLD >II
  • Renal dysfunction defined as serum-creatinine >1.5mg/dl
  • acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support
  • single vessel grafting
  • disabling neuropsychiatric disorders (severe dementia, Alzheimer's disease, schizophrenia, depression, low preoperative cognitive state (MMSE at baseline <25), history of stroke with residuals, increased intracranial pressure
  • Hypersensitivity to the study medication
  • Presumed uncooperativeness or legal incapacity

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

50 participants in 2 patient groups, including a placebo group

Xenon and propofol
Active Comparator group
Treatment:
Drug: Xenon and propofol
propofol
Placebo Comparator group
Treatment:
Drug: propofol

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems