Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect

Università degli Studi di Sassari

Status: Completed

Conditions: Dental Caries; Periodontal Diseases

Treatments: Dietary Supplement: 22% Xylitol Gum; Dietary Supplement: 100% Xylitol Gum

Study type: Interventional

Funder types: Other

Identifiers

NCT03971981

SS-15884-GC

Details and patient eligibility

About

a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol. The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums. Subjects were instructed to consume the products as they normally would be consumed.

Full description

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Enrollment: 32 patients

Sex: All

Ages: 19 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• good general health,
• the absence of diseases that can alter the saliva secretion rate
• a stimulated saliva flow at least of 1 ml/min.

Exclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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32 participants in 2 patient groups

100% Xylitol

Experimental group

Description:

The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums.

Treatment:

Dietary Supplement: 100% Xylitol Gum

22% Xylitol

Experimental group

Description:

The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums.

Treatment:

Dietary Supplement: 22% Xylitol Gum