Yellow Fever Human Infection Model With YF-17D (YF-INFECT)

Leiden University Medical Center (LUMC)

Status: Enrolling

Conditions: Yellow Fever

Treatments: Drug: Yellow Fever Vaccine

Study type: Interventional

Funder types: Other

Identifiers

NCT05901454

NL70951.058.19

Details and patient eligibility

About

No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.

Full description

No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-50 years

Exclusion criteria

• contraindication to receive YF-17D (immune deficiency, thymus illness)
• previous YF vaccination
• pregnancy
• chicken egg allergy
• hypersensitivity to any other substance in the YF-17D vaccine
• interval of < 4 weeks of another live attenuated vaccine

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

intervention arm

Other group

Description:

yellow fever vaccine arm (all participants receive the standard yellow fever vaccine (Stamaril)

Treatment:

Drug: Yellow Fever Vaccine