YKL-40 and IL-6 Levels in Periodontal Disease

Zeynep Pinar KELES

Status: Completed

Conditions: Periodontal Diseases

Treatments: Procedure: Nonsurgical periodontal therapy

Study type: Observational

Funder types: Other

Identifiers

NCT03507868

2016/1003

Details and patient eligibility

About

The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.

Full description

This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.

Enrollment: 52 patients

Sex: All

Ages: 26 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Group 1 Inclusion Criteria:

• No bone and attachment loss,
• GI=0, PPD≤3mm, CAL≤3mm
• Systematically healthy patients

Group 2 Inclusion Criteria:

• GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
• Systematically healthy patients

Exclusion criteria

• Aggressive Periodontitis,
• Patients with any other systemic diseases,
• Pregnant women and those in the lactation period,
• Patients with smoking habit and taking medication
• Patients received periodontal therapy in last 6 month

Trial design

52 participants in 2 patient groups

Group 1

Description:

Periodontally healthy individuals

Group 2

Description:

Chronic periodontitis patients

Treatment:

Procedure: Nonsurgical periodontal therapy