Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis

The University of Alabama at Birmingham

Status: Completed

Conditions: Myasthenia Gravis; Amyotrophic Lateral Sclerosis

Treatments: Behavioral: yogic breathing exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05979688

IRB-300011535

Details and patient eligibility

About

The aim of this study is to understand how well a 6-week virtual yogic breathing exercise program (YBEP) will improve breathing, speech, and emotional well-being in people with amyotrophic lateral sclerosis (ALS).

Full description

The study will employ a RCT to test the two hypotheses. The study will incorporate a 2 x 2 two-way factorial design with repeated measures at three time points. The two between-subject factor conditions will be participation in a yogic breathing exercise program (YBEP) versus a waitlist control condition that will be evaluated at baseline, and immediately post-program. Thirty adults with ALS will be recruited for this study.

Hypothesis #1: Adults with ALS who participate in a YBEP will demonstrate improvement in breathing, and emotional well-being compared to waitlist controls at the conclusion of a 6-week YBEP.

Enrollment: 13 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. confirmed ALS or myasthenia gravis diagnosis
2. age >18 yrs old;
3. ability to follow multistep commands,
4. on a stable dose of medications for >60 days,
5. FVC ≥30% predicted,
6. access to internet and a computer or smartphone that can perform videoconferencing.

Exclusion criteria

1. life expectancy is less than 6 months,
2. severe hearing or visual impairments that prevent online learning (breathing exercise), or
3. current participation in another clinical trial during the study period that can affect the outcomes of the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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13 participants in 2 patient groups

Yogic breathing exercise

Experimental group

Description:

Participation in a 6 weekly virtual yogic breathing exercise training with 1-3 sessions per week.

Treatment:

Behavioral: yogic breathing exercise

Waitlist control

No Intervention group

Description:

Participation in usual daily activities