Young Smokers Have Impaired Airway Defense

University of Sao Paulo

Status: Completed

Conditions: Smoking

Study type: Observational

Funder types: Other

Identifiers

NCT01877291

CEP-FMUSP 147-13

Details and patient eligibility

About

Background: Smoking is a key factor for development and progression of chronic obstructive pulmonary disease (COPD). Although persons with COPD often have concomitant nasal disease, there are few studies that report physiological or inflammatory changes in the upper airways in young asymptomatic smokers. The investigators investigated physiologic and inflammatory changes in the nasal and lower airways of young smokers and if these changes were related to smoking history.

Methods: Seventy-two subjects aged ≤ 35 years (32 healthy nonsmokers and 40 young smokers) participated in this study. The investigators measured nasal mucociliary clearance (MCC), nasal mucus physical properties, cell count, myeloperoxidase and cytokines concentrations in nasal lavage fluid, exhaled breath condensate (EBC) pH and lung function.

Enrollment: 72 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy nonsmokers
• asymptomatic smokers
• after obtaining written informed consent

Exclusion criteria

• inability to understand and follow commands
• previous nasal surgery
• respiratory infection in the previous 30 days
• reported or diagnosed asthma

Trial design

72 participants in 3 patient groups

Nonsmokers

Description:

Young healthy nonsmokers

Smokers<2.5 pack years

Description:

Young "healthy" or asymptomatic smokers (aged \< 35 y.o.) with smoking history \<2.5 pack years

Smokers≥ 2.5 pack-years

Description:

Young "healthy" or asymptomatic smokers (aged \< 35 y.o.) with smoking history ≥ 2.5 pack-years