The trial is taking place at:
H

Healthcare Research Network | Flossmoor, IL

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Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment

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BeiGene

Status and phase

Enrolling
Phase 2

Conditions

Waldenstrom Macroglobulinemia
Marginal Zone Lymphoma
Mantle Cell Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Treatments

Drug: Zanubrutinib

Study type

Interventional

Funder types

Industry

Identifiers

NCT04116437
BGB-3111-215

Details and patient eligibility

About

The primary objective of this study is to evaluate the safety of zanubrutinib (also known as BGB-3111) in chronic lymphocytic leukemia/small lymphocytic lymphoma, Waldenström macroglobulinemia, mantle cell lymphoma, or marginal zone lymphoma patients who have become intolerant of prior ibrutinib and/or acalabrutinib treatment, by comparing intolerance to adverse event profile as assessed by the recurrence and the change in severity of adverse events.

Enrollment

90 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Key Inclusion Criteria: 1. Participants must meet protocol defined disease criteria requiring treatment for their respective disease prior to initiation of ibrutinib or acalabrutinib 2. Ibrutinib and acalabrutinib intolerance is defined as an unacceptable toxicity where, in the opinion of the investigator, treatment should be discontinued in spite of optimal supportive care as a result of one of the following: 1. For ibrutinib and acalabrutinib intolerance events: * 1 or more ≥ Grade 2 nonhematologic toxicities for \>7 days (with or without treatment) * 1 or more ≥ Grade 3 nonhematologic toxicity of any duration * 1 or more Grade 3 neutropenia with infection or fever of any duration; or * Grade 4 heme toxicity which persists to the point that the investigator chose to stop therapy due to toxicity NOT progression. 2. For acalabrutinib intolerance events only; * 1 or more ≥ Grade 1 nonhematologic toxicities of any duration with \> 3 recurrent episodes; or * 1 or more ≥ Grade 1 nonhematologic toxicities for \> 7 days (with or without treatment); or * Inability to use acid-reducing agents or anticoagulants (eg, proton pump inhibitors, warfarin) due to concurrent acalabrutinib use 3. Ibrutinib and/or acalabrutinib-related ≥ Grade 2 toxicities must have resolved to ≤ Grade 1 or baseline prior to initiating treatment with zanubrutinib. Grade 1 acalabrutinib-related toxicities must have resolved to Grade 0 or baseline prior to initiating treatment with zanubrutinib. 4. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 5. Absolute neutrophil count (ANC) ≥ 1000/mm\^3 with or without growth factor support and platelet count ≥ 50,000/mm\^3 (may be post-transfusion), on or prior to C1D1 of zanubrutinib Key Exclusion Criteria: 1. Clinically significant cardiovascular disease including the following: 1. Myocardial infarction within 6 months before the Screening 2. Unstable angina within 3 months before the Screening 3. New York Heart Association class III or IV congestive heart failure 4. History of sustained ventricular tachycardia, ventricular fibrillation, and/or Torsades de Pointes 5. QT interval corrected by Fridericia's formula \> 480 milliseconds 6. History of Mobitz II second-degree or third-degree heart block without a permanent pacemaker in place 2. History of central nervous system (CNS) hemorrhage 3. Documented progressive disease (PD) during ibrutinib and/or acalabrutinib treatment. 4. Have received any anticancer therapy (other than immunotherapy) for CLL/SLL, WM, MCL, and MZL \< 7 days before any Screening assessments are performed or any immunotherapy treatment, taken alone or as part of a chemoimmunotherapy regimen, \< 4 weeks before any Screening assessments are performed 5. Requires ongoing need for corticosteroid treatment \> 10 mg daily of prednisone or equivalent corticosteroid. Note: Systemic corticosteroids must be fully tapered off/discontinued ≥ 5 days before the first dose of study drug is administered. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

90 participants in 1 patient group

Zanubrutinib
Experimental group
Description:
Cohort 1: Chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Waldenström macroglobulinemia (WM), mantle cell lymphoma (MCL), or marginal zone lymphoma (MZL) previously treated with ibrutinib Cohort 2: Chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Waldenström macroglobulinemia (WM), mantle cell lymphoma (MCL), or marginal zone lymphoma (MZL) previously treated with acalabrutinib alone/with ibrutinib
Treatment:
Drug: Zanubrutinib

Trial contacts and locations

26

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Central trial contact

BeiGene

Data sourced from clinicaltrials.gov

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