Zinc Supplement Before or With Food in Generally Healthy Men

UCSF Benioff Children's Hospital Oakland

Status: Completed

Conditions: Inflammation; Dyslipidemias; Zinc Excess; Zinc Deficiency

Treatments: Dietary Supplement: Zinc supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT03619421

CHO23

Details and patient eligibility

About

The purpose of this study is to determine the influence of food consumption timing on the body's response to a zinc supplement

Full description

This research is a dietary intervention study designed to evaluate the effect of the food consumption timing on the absorption of zinc supplement.

The main objective is to measure plasma zinc in generally healthy male subjects, who will consume zinc supplement with food or 30-min before food for 2-weeks.

In addition to the primary objectives, correlations in enzyme activity with changes in fat metabolism, namely circulating triglyceride and cholesterol, will be determined. This will enable the determination of the effect of a low Zn intake on various aspects of dyslipidemia.

Enrollment: 35 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• willing to stop supplementation 4 weeks prior to start of the study
• has an operative understanding of English
• no plans to move from the area during the study period
• regularly eat breakfast

Exclusion criteria

• Chronic or acute metabolic disease
• smoker or user of nicotine products
• history of alcohol abuse, or use of illicit drugs (incl marijuana)
• Is underweight or overweight, body mass index (BMI) < 18 or > 30 kg/m2

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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35 participants in 2 patient groups

Supplement with food

Experimental group

Description:

Zinc supplement to be taken at time of breakfast consumption

Treatment:

Dietary Supplement: Zinc supplement

supplement prior to food

Experimental group

Description:

Zinc supplement to be taken 30-min before breakfast consumption

Treatment:

Dietary Supplement: Zinc supplement