Zonisamide in the Treatment of Essential Tremor

Loma Linda University (LLU)

Status: Terminated

Conditions: Essential Tremor

Treatments: Drug: Zonisamide

Study type: Interventional

Funder types: Other

Identifiers

NCT00616343

OSR#53157

Details and patient eligibility

About

The purpose of this study is to determine if Zonisamide is effective in reducing tremors in patients with Essential Tremor.

Full description

The subjects will remain on their usual medication and a baseline assessment using the Fahn Tolosa Marin tremor rating scale will be performed and will be video taped.

Enrollment: 9 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for definite or probable Essential Tremor.
2. Age: 18 years or over.
3. Willingness and ability to comply with the study requirements and give informed consent.

Exclusion criteria

1. Known history of psychiatric disorder, major depression, dementia, aplastic anemia, or Stevens-Johnson syndrome.
2. Known alcohol or substance abuse in previous 12 months.
3. Positive pregnancy test.
4. Unwillingness to use adequate contraceptive methods if of childbearing potential.
5. Known allergy to sulfonamides.
6. Laboratory abnormalities prior to onset of trial.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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9 participants in 1 patient group

Zonisamide

Active Comparator group

Treatment:

Drug: Zonisamide