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Find clinical trials for Acute Myeloid Leukemia (AML) in Charlotte, NC

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Related conditions:

Acute Myeloid Leukemia
Leukemia
Myeloid Leukemia
Myelodysplastic Syndromes
Preleukemia
Syndrome
Cancer

Acute Myeloid Leukemia (AML) trials near Charlotte, NC, USA:

A Study of JNJ-75276617 in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

The purpose of this study is to determine the recommended Phase 2 dose (RP2D) candidate(s) of JNJ-75276617 in combination with AML directed ...

Enrolling
Leukemia, Myeloid, Acute
Drug: Azacitidine (AZA)
Drug: Cytarabine

Phase 1

Janssen (J&J Innovative Medicine)
Janssen (J&J Innovative Medicine)

Charlotte, North Carolina, United States and 30 other locations

PK of APG-2575 in combination with Azacitidine in the patients with AML/MPAL or MDS/CMML. The study consists of dose escalation (Part I) and...

Enrolling
AML, Adult
Drug: APG 2575 ramp up arm

Phase 1, Phase 2

Ascentage Pharma Group
Ascentage Pharma Group

Charlotte, North Carolina, United States and 8 other locations

This trial will seek to extend the preliminary findings of efficacy of MBG453 in combination with hypomethylating agents (HMA) by evaluating MBG453 i...

Active, not recruiting
Acute Myeloid Leukemia
Drug: Venetoclax
Drug: MBG453

Phase 2

Novartis
Novartis

Charlotte, North Carolina, United States and 27 other locations

subjects with previously treated or untreated with high risk factor acute myeloid leukemia (AML). Venetoclax and ...

Enrolling
Acute Myeloid Leukemia, Adult
Drug: ADI-PEG 20

Phase 1

Polaris Group

Charlotte, North Carolina, United States and 2 other locations

cytotoxic chemotherapy in induction-eligible patients with acute myeloid leukemia.This study involves the following:* Vene...

Enrolling
Acute Myeloid Leukemia
Drug: Venetoclax
Drug: Azacitidine

Phase 2

Mass General Brigham
Mass General Brigham

Charlotte, North Carolina, United States and 8 other locations

LAVA-051 in patients with relapsed or refractory Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM), or Acute Myeloid...

Active, not recruiting
Chronic Lymphocytic Leukemia
Acute Myeloid Leukemia
Biological: Interleukin 2
Biological: LAVA-051

Phase 1, Phase 2

Lava Therapeutics

Charlotte, North Carolina, United States and 13 other locations

or refractory (R/R) lymphoma* multiple myeloma* newly diagnosed acute myeloid leukemia (AML).This trial will be c...

Active, not recruiting
Acute Myeloid Leukemia
Multiple Myeloma
Drug: Dexamethasone
Drug: Venetoclax

Phase 1

Pfizer
Pfizer

Charlotte, North Carolina, United States and 61 other locations

Some people with MDS have a risk of the disease progressing to acute myeloid leukemia (AML), and a risk of death ...

Active, not recruiting
Myelodysplastic Syndrome (MDS)
Drug: Placebo
Drug: Azacitidine

Phase 3

AbbVie
AbbVie

Charlotte, North Carolina, United States and 221 other locations

This is a phase I/II Study of Nivolumab in Combination with 5-azacytidine in pediatric patients with relapsed/refractory acute myeloid...

Active, not recruiting
AML, Childhood
Drug: 5-azacytidine
Drug: Nivolumab

Phase 1, Phase 2

Therapeutic Advances in Childhood Leukemia Consortium

Charlotte, North Carolina, United States and 11 other locations

Tamibarotene is being studied as a treatment for participants with a type of leukemia called acute myeloid leukemia...

Enrolling
Acute Myeloid Leukemia
Drug: Azacitidine
Drug: Venetoclax

Phase 2

Syros Pharmaceuticals

Charlotte, North Carolina, United States and 30 other locations

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