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Find clinical trials for Adenocarcinoma in Durham, NC

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Cancer
Carcinoma
Pancreatic Cancer
Colorectal Cancer
Stomach Cancer
Esophageal Cancer
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Adenocarcinoma trials near Durham, NC, USA:

A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal Cancer (DisTinGuish)

as First-Line or Second-Line Therapy in Adult Patients with Inoperable, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma...

Active, not recruiting
Gastric Adenocarcinoma
Gastric Cancer
Drug: Tislelizumab 200mg
Drug: DKN-01 400mg

Phase 2

Leap Therapeutics

Durham, North Carolina, United States and 47 other locations

mFOLFIRINOX alone in participants with resected pancreatic ductal adenocarcinoma (PDAC) who have not received prior systemic anti-cancer tre...

Enrolling
Adenocarcinoma, Pancreatic Ductal
Drug: mFOLFIRINOX
Drug: Autogene cevumeran

Phase 2

Genentech
Genentech

Durham, North Carolina, United States and 44 other locations

participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignatur...

Enrolling
Endometrial Adenocarcinoma
Urothelial Carcinoma
Diagnostic Test: OncoSignature
Drug: ACR-368

Phase 1, Phase 2

Acrivon Therapeutics

Chapel Hill, North Carolina, United States and 66 other locations

first-line treatment of participants with locally advanced unresectable or metastatic gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma...

Active, not recruiting
Advanced Upper Gastrointestinal Tract Adenocarcinoma
Drug: Domvanalimab
Drug: Zimberelimab

Phase 3

Arcus Biosciences
Arcus Biosciences

Durham, North Carolina, United States and 203 other locations

Status recently updated

after complete surgical resection (R0) in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive, as determined by the Sponso...

Not yet enrolling
Enrolling
Non-small Cell Lung Cancer
Drug: Pemetrexed
Drug: Rilvegostomig

Phase 3

AstraZeneca
AstraZeneca

Durham, North Carolina, United States and 186 other locations

Claudin 18.2 protein, or CLDN18.2 is a protein found on cells in the digestive system. It is also found on some tumors. Researchers are looking at wa...

Enrolling
Gastroesophageal Junction (GEJ) Adenocarcinoma
Pancreatic Adenocarcinoma
Drug: ASP2138
Drug: Irinotecan

Phase 1

Astellas
Astellas

Durham, North Carolina, United States and 36 other locations

The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trast...

Active, not recruiting
Gastroesophageal Junction Adenocarcinoma
Gastric Neoplasms
Drug: Oxaliplatin
Biological: Trastuzumab

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Durham, North Carolina, United States and 191 other locations

Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plu...

Enrolling
Esophageal Adenocarcinoma
Barretts Esophagus With Dysplasia
Diagnostic Test: Esophagogastroduodenoscopy
Device: EsoGuard (lab assay)
Lucid Diagnostics

Chapel Hill, North Carolina, United States and 37 other locations

This is an open-label, Phase 1/2 study to determine the safety, tolerability, and efficacy of APL-5125 for the treatment of selected locally advanced...

Enrolling
Endometrial Adenocarcinoma
Appendiceal Adenocarcinoma
Drug: APL-5125

Phase 1, Phase 2

Apollo Therapeutics

Durham, North Carolina, United States and 6 other locations

with locally advanced and unresectable or metastatic pancreatic adenocarcinoma. Subjects who are eligible to receive two FDA approved first ...

Enrolling
Metastatic Pancreatic Adenocarcinoma
Locally Advanced Unresectable Pancreatic Adenocarcinoma
Other: NEAAR Medical Food
Faeth Therapeutics

Raleigh, North Carolina, United States and 11 other locations

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