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Find clinical trials for Adenocarcinoma in Durham, NC

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Related conditions:

Carcinoma
Cancer
Pancreatic Cancer
Stomach Cancer
Colorectal Cancer
Prostatic Cancer
Esophageal Cancer

Adenocarcinoma trials near Durham, NC, USA:

A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal Cancer (DisTinGuish)

as First-Line or Second-Line Therapy in Adult Patients with Inoperable, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma...

Active, not recruiting
Gastric Adenocarcinoma
Gastric Cancer
Drug: Capecitabine 1000mg/ m2 BID
Drug: DKN-01 600mg

Phase 2

Leap Therapeutics

Durham, North Carolina, United States and 47 other locations

participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignatur...

Enrolling
Endometrial Adenocarcinoma
Urothelial Carcinoma
Drug: ACR-368
Diagnostic Test: OncoSignature

Phase 1, Phase 2

Acrivon Therapeutics

Chapel Hill, North Carolina, United States of America and 66 other locations

first-line treatment of participants with locally advanced unresectable or metastatic gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma...

Enrolling
Advanced Upper Gastrointestinal Tract Adenocarcinoma
Drug: Capecitabine
Drug: Fluorouracil

Phase 3

Arcus Biosciences
Arcus Biosciences

Durham, North Carolina, United States and 196 other locations

Claudin 18.2 protein, or CLDN18.2 is a protein found on cells in the digestive system. It is also found on some tumors. Researchers are looking at wa...

Enrolling
Gastroesophageal Junction (GEJ) Adenocarcinoma
Pancreatic Adenocarcinoma
Drug: ASP2138

Phase 1

Astellas
Astellas

Durham, North Carolina, United States and 21 other locations

This study is being done to see if tucatinib with trastuzumab, ramucirumab and paclitaxel works better than ramucirumab and paclitaxel to treat HER2-...

Active, not recruiting
Esophageal Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma
Drug: paclitaxel
Drug: trastuzumab

Phase 2, Phase 3

Seagen
Seagen

Durham, North Carolina, United States and 47 other locations

The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trast...

Active, not recruiting
Gastroesophageal Junction Adenocarcinoma
Gastric Neoplasms
Drug: Oxaliplatin
Drug: Cisplatin

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Durham, North Carolina, United States and 191 other locations

Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plu...

Enrolling
Esophageal Adenocarcinoma
Barretts Esophagus With Dysplasia
Diagnostic Test: Esophagogastroduodenoscopy
Device: EsoGuard (lab assay)
Lucid Diagnostics

Chapel Hill, North Carolina, United States and 37 other locations

with locally advanced and unresectable or metastatic pancreatic adenocarcinoma. Subjects who are eligible to receive two FDA approved first ...

Enrolling
Metastatic Pancreatic Adenocarcinoma
Locally Advanced Unresectable Pancreatic Adenocarcinoma
Other: NEAAR Medical Food
Faeth Therapeutics

Raleigh, North Carolina, United States and 11 other locations

This trial studies tucatinib to find out if it is safe when given with trastuzumab and other anti-cancer drugs (pembrolizumab, FOLFOX, and CAPOX). It...

Enrolling
Esophageal Adenocarcinoma
Gastric Adenocarcinoma
Drug: tucatinib
Drug: trastuzumab

Phase 1, Phase 2

Seagen
Seagen

Durham, North Carolina, United States and 21 other locations

The ProVent study is a randomized, open-label study designed to assess the efficacy of sipuleucel-T in reducing the progression of lower risk non-met...

Active, not recruiting
Adenocarcinoma of the Prostate
Biological: sipuleucel-T

Phase 3

Dendreon

Raleigh, North Carolina, United States and 55 other locations

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