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Find clinical trials for Adenocarcinoma in Durham, NC

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Pancreatic Cancer
Non-Small-Cell Lung Carcinoma
Colorectal Cancer
Stomach Cancer
Cancer
Esophageal Cancer
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Adenocarcinoma trials near Durham, NC, USA:

Locations recently updated

A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (AndroMETa-GEA)

participants to treat locally advanced unresectable or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma (mGEA).T...

Enrolling
Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma
Esophageal Adenocarcinoma
Drug: Budigalimab
Drug: Oxaliplatin

Phase 2

AbbVie
AbbVie

Durham, North Carolina, United States and 35 other locations

The purpose of this study is to combine standard radiation therapy with drugs that encourages the body's immune system against cancer cells and simul...

Enrolling
Pancreatic Ductal Adenocarcinoma
Drug: Zimberelimab
Drug: Modified FOLFIRINOX

Phase 2

Gulam Manji

Chapel Hill, North Carolina, United States and 4 other locations

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.

Active, not recruiting
PDAC - Pancreatic Ductal Adenocarcinoma
PDAC
Drug: 5-fluorouracil
Drug: leucovorin

Phase 3

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 59 other locations

T-cells in Subjects with Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma...

Active, not recruiting
Esophageal Cancer
Gastric Cancer
Biological: LB1908

Phase 1

Legend Biotech

Durham, North Carolina, United States and 8 other locations

first-line treatment of participants with locally advanced unresectable or metastatic gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma...

Active, not recruiting
Advanced Upper Gastrointestinal Tract Adenocarcinoma
Drug: Domvanalimab
Drug: Zimberelimab

Phase 3

Arcus Biosciences
Arcus Biosciences

Durham, North Carolina, United States and 212 other locations

Zolbetuximab is being studied in people with cancer in and around the stomach or where the food pipe (esophagus) joins the stomach, called gastroesop...

Enrolling
Metastatic Gastric Adenocarcinoma or Cancer
Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer
Drug: 5-fluorouracil (5-FU)
Drug: Capecitabine

Phase 3

Astellas
Astellas

Chapel Hill, North Carolina, United States and 136 other locations

This is an open label Phase 2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or with ultra-low dose gemcitabine (ULDG) sensitiza...

Enrolling
Endometrial Adenocarcinoma
Drug: ACR-368
Drug: Gemcitabine

Phase 2

Acrivon Therapeutics

Chapel Hill, North Carolina, United States and 69 other locations

Claudin 18.2 protein, or CLDN18.2 is a protein found on cells in the digestive system. It is also found on some tumors. Researchers are looking at wa...

Enrolling
Gastroesophageal Junction (GEJ) Adenocarcinoma
Pancreatic Adenocarcinoma
Drug: Irinotecan
Drug: Leucovorin

Phase 1

Astellas
Astellas

Durham, North Carolina, United States and 43 other locations

after complete surgical resection (R0) in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive, as determined by the Sponso...

Enrolling
Non-small Cell Lung Cancer
Drug: Pemetrexed
Drug: Rilvegostomig

Phase 3

AstraZeneca
AstraZeneca

Durham, North Carolina, United States and 224 other locations

Some people with pancreatic ductal cancer (PDAC) have a protein called Claudin 18.2 (CLDN18.2) in their tumor. ASP2138 is thought to work by binding...

Enrolling
Pancreatic Ductal Adenocarcinoma
Drug: Irinotecan
Drug: Capecitabine

Phase 1

Astellas
Astellas

Durham, North Carolina, United States and 1 other location

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