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Find clinical trials for Adenocarcinoma in Pittsburgh, PA

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Related conditions:

Pancreatic Cancer
Colorectal Cancer
Non-Small-Cell Lung Carcinoma
Stomach Cancer
Carcinoma
Esophageal Cancer
Cancer

Adenocarcinoma trials near Pittsburgh, PA, USA:

A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015) (TroFuse-015)

(TPC) in participants with advanced/metastatic gastroesophageal adenocarcinoma. The primary hypothesis of this study is sacituzumab tirumote...

Enrolling
Gastroesophageal Cancer
Drug: Rescue medication
Drug: Supportive care measures

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Pittsburgh, Pennsylvania, United States and 165 other locations

resectable gastric, gastroesophageal junction (GEJ), or esophageal adenocarcinoma who have not received previous treatment for the disease....

Enrolling
Gastroesophageal Adenocarcinoma
Drug: Rilvegostomig
Drug: 5-Fluorouracil (5-FU)

Phase 2

AstraZeneca
AstraZeneca

Pittsburgh, Pennsylvania, United States and 63 other locations

The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel and gemcitab...

Enrolling
Metastatic Pancreatic Ductal Adenocarcinoma
Drug: Gemcitabine
Drug: Nab-paclitaxel

Phase 3

Arcus Biosciences
Arcus Biosciences

Pittsburgh, Pennsylvania, United States and 135 other locations

and immunogenicity of novel combination therapies in participants with locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma...

Enrolling
Gastric Cancer
Drug: AZD0901
Drug: Capecitabine

Phase 2

AstraZeneca
AstraZeneca

Pittsburgh, Pennsylvania, United States and 43 other locations

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.

Enrolling
PDAC - Pancreatic Ductal Adenocarcinoma
PDAC
Drug: 5-fluorouracil
Drug: leucovorin

Phase 3

Revolution Medicines
Revolution Medicines

Pittsburgh, Pennsylvania, United States and 59 other locations

esophageal adenocarcinoma.This substudy will have two phases: a safety lead-in phase and an efficacy phase. The safety lead-in phase will b...

Enrolling
Gastroesophageal Adenocarcinoma
Esophageal Cancer
Drug: Levoleucovorin
Drug: Capecitabine

Phase 1, Phase 2

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Pittsburgh, Pennsylvania, United States and 42 other locations

the treatment of participants with advanced or metastatic gastric adenocarcinoma, gastroesophageal junction (GEJ) adenocarcinoma, o...

Enrolling
Gastroesophageal Adenocarcinoma
Esophageal Cancer
Biological: Ramucirumab
Biological: Sacituzumab Tirumotecan

Phase 1, Phase 2

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Pittsburgh, Pennsylvania, United States and 42 other locations

This is an open label Phase 2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or with ultra-low dose gemcitabine (ULDG) sensitiza...

Enrolling
Endometrial Adenocarcinoma
Drug: ACR-368
Drug: Gemcitabine

Phase 2

Acrivon Therapeutics

Pittsburgh, Pennsylvania, United States and 68 other locations

after complete surgical resection (R0) in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive, as determined by the Sponso...

Enrolling
Non-small Cell Lung Cancer
Drug: Pemetrexed
Drug: Rilvegostomig

Phase 3

AstraZeneca
AstraZeneca

Pittsburgh, Pennsylvania, United States and 221 other locations

efficacy of Spevatamig (PT886). Patients with the following tumor types will be eligible for screening: unresectable or metastatic gastric adenocarcinoma...

Enrolling
Pancreatic Ductal Adenocarcinoma
Gastric or Gastroesophageal Junction Adenocarcinoma
Drug: Gemcitabine
Drug: KEYTRUDA® (pembrolizumab)

Phase 1, Phase 2

Phanes Therapeutics

Pittsburgh, Pennsylvania, United States and 10 other locations

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