Find clinical trials for Adenocarcinoma in Pittsburgh, PA

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Adenocarcinoma trials near Pittsburgh, PA, USA:

A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015) (TroFuse-015)

(TPC) in participants with advanced/metastatic gastroesophageal adenocarcinoma. The primary hypothesis of this study is sacituzumab tirumote...

Enrolling

Gastroesophageal Cancer

Drug: Rescue medication

Drug: Supportive care measures

Phase 3

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Merck Sharp & Dohme (MSD)

Pittsburgh, Pennsylvania, United States and 152 other locations

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PRISM-1)

The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel and gemcitab...

Enrolling

Metastatic Pancreatic Ductal Adenocarcinoma

Drug: Gemcitabine

Drug: Nab-paclitaxel

Phase 3

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Arcus Biosciences

Pittsburgh, Pennsylvania, United States and 53 other locations

Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

and immunogenicity of novel combination therapies in participants with locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma...

Enrolling

Gastric Cancer

Drug: AZD0901

Drug: Capecitabine

Phase 2

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AstraZeneca

Pittsburgh, Pennsylvania, United States and 43 other locations

A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)

combinations in participants with metastatic Pancreatic Ductal Adenocarcinoma (PDAC).Two cohorts will be enrolled in parallel in this study:...

Active, not recruiting

Pancreatic Adenocarcinoma

Drug: Gemcitabine

Drug: Bevacizumab

Phase 1, Phase 2

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Roche

Pittsburgh, Pennsylvania, United States and 18 other locations

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

esophageal adenocarcinoma.This substudy will have two phases: a safety lead-in phase and an efficacy phase. The safety lead-in phase will b...

Enrolling

Gastroesophageal Adenocarcinoma

Esophageal Cancer

Drug: Levoleucovorin

Drug: Capecitabine

Phase 1, Phase 2

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Merck Sharp & Dohme (MSD)

Pittsburgh, Pennsylvania, United States and 35 other locations

9-ING-41 Plus Retifanlimab and Gemcitabine/Nab-Paclitaxel in Patients With Advanced Pancreatic Adenocarcinoma (RiLEY)

This trial examines how Pancreatic Adenocarcinoma reacts to the addition of 9-ING-41 and retifanlimab to the standard of care chemotherapy t...

Active, not recruiting

Pancreatic Adenocarcinoma

Drug: Abraxane

Drug: 9-ING-41

Phase 2

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Anwaar Saeed

Pittsburgh, Pennsylvania, United States and 1 other location

Spevatamig (PT886) for Treatment of Patients with Metastatic/Advanced Gastric, Gastroesophageal Junction and Pancreatic Adenocarcinoma (the TWINPEAK Study)

efficacy of Spevatamig (PT886). Patients with the following tumor types will be eligible for screening: unresectable or metastatic gastric adenocarcinoma...

Enrolling

Pancreatic Ductal Adenocarcinoma

Gastric or Gastroesophageal Junction Adenocarcinoma

Drug: Gemcitabine

Drug: Paclitaxel

Phase 1, Phase 2

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Phanes Therapeutics

Pittsburgh, Pennsylvania, United States and 5 other locations

9-ING-41 Combined with Retifanlimab, Plus Modified FOLFIRINOX for Patients with Advanced Pancreatic Adenocarcinoma (RiLEY)

This is a study of the combination of 9 ING-41 (elraglusib) and retifanlimab plus mFOLFIRINOX in patients with pancreatic cancer without prior system...

Begins enrollment in 1 month

Pancreatic Adenocarcinoma

Drug: Chemotherapy

Drug: Retifanlimab

Phase 1

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Anwaar Saeed

Pittsburgh, Pennsylvania, United States

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