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Find clinical trials for Adenocarcinoma in St Louis, MO

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Adenocarcinoma trials near St Louis, MO, USA:

Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma

Patients with advanced pancreas adenocarcinoma will be randomized on a 6:1 basis to receive standard of care chemotherapy followed by adapti...

Enrolling
Pancreas Adenocarcinoma
Pancreas Cancer
Drug: Defactinib
Procedure: Research blood draw

Phase 2

The Washington University
The Washington University

Saint Louis, Missouri, United States

The investigators hypothesize that MK2 inhibition may improve efficacy of mFOLFIRINOX chemotherapy for patients with pancreatic ductal adenocarcinoma...

Begins enrollment in 1 month
Metastatic Pancreatic Ductal Adenocarcinoma
Cancer of the Pancreas
Drug: mFOLFIRINOX
Drug: Zunsemetinib

Phase 1

The Washington University
The Washington University

Saint Louis, Missouri, United States

This is a Phase 1 study to assess the safety and efficacy of ELI-002 immunotherapy (a lipid-conjugated immune-stimulatory oligonucleotide \[Amph-CpG-...

Active, not recruiting
Pancreatic Ductal Adenocarcinoma
NRAS G12D
Drug: ELI-002 2P

Phase 1

Elicio Therapeutics
Elicio Therapeutics

Saint Louis, Missouri, United States and 9 other locations

as monotherapy (Part C) and in combination with first-line SoC treatment (Part D) in patients with advanced or metastatic pancreatic adenocarcinoma...

Enrolling
Pancreatic Cancer
Drug: SOT102

Phase 1, Phase 2

SOTIO
SOTIO

Saint Louis, Missouri, United States and 7 other locations

and safety of AZD0901 compared to Investigator's choice of therapy as 2L+ treatment for participants with advanced or metastatic gastric or GEJ adenocarcinoma...

Enrolling
Gastroesophageal Junction Cancer
Gastric Cancer
Drug: AZD0901
Drug: Docetaxel

Phase 3

AstraZeneca
AstraZeneca

Saint Louis, Missouri, United States and 165 other locations

The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trast...

Active, not recruiting
Gastroesophageal Junction Adenocarcinoma
Gastric Neoplasms
Drug: Oxaliplatin
Biological: Trastuzumab

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Saint Louis, Missouri, United States and 191 other locations

The purpose of this study is to assess the efficacy and safety of lenvatinib (E7080/MK-7902) plus pembrolizumab (MK-3475) plus chemotherapy compared...

Active, not recruiting
Advanced/Metastatic Gastroesophageal Adenocarcinoma
Drug: 5-FU
Biological: Lenvatinib

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Saint Louis, Missouri, United States and 176 other locations

Phase I Study of NT-112, an autologous T-cell therapy product genetically engineered to express an HLA-C\*08:02-restricted T cell receptor (TCR), tar...

Enrolling
Pancreatic Ductal Adenocarcinoma
Endometrial Cancer
Biological: NT-112: Autologous, engineered T Cells targeting KRAS G12D

Phase 1

Neogene Therapeutics

St. Louis, Missouri, United States and 11 other locations

Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plu...

Enrolling
Esophageal Adenocarcinoma
Barretts Esophagus With Dysplasia
Diagnostic Test: Esophagogastroduodenoscopy
Device: EsoGuard (lab assay)
Lucid Diagnostics

Saint Louis, Missouri, United States and 37 other locations

Zolbetuximab is being studied as a treatment for people with pancreatic cancer. Most people with pancreatic cancer have a protein called Claudin 18.2...

Active, not recruiting
Metastatic Pancreatic Adenocarcinoma
Metastatic Pancreatic Cancer
Drug: nab-paclitaxel
Drug: gemcitabine

Phase 2

Astellas
Astellas

Creve Coeur, Missouri, United States and 135 other locations

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