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with histologically or cytologically confirmed stage IV colorectal cancer coming form three different patient populations:* Cohort 1a: 6 pat...
Phase 1
Aurora, Colorado, United States and 11 other locations
and irinotecan) in participants with metastatic colorectal cancer (mCRC). The main goals of this study are to:* Evaluate the efficacy of the...
Phase 2
Denver, Colorado, United States and 13 other locations
Solid tumours are abnormal lumps of tissue that can occur in different parts of the body. The tumours involved in this study have specific genetic ch...
Phase 1, Phase 2
Denver, Colorado, United States and 21 other locations
This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept effi...
Phase 1
Denver, Colorado, United States and 10 other locations
RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of existing...
Phase 1
Denver, Colorado, United States and 2 other locations
Data from a prior phase II study of single agent cabozantinib in metastatic, refractory colorectal cancer (NCT03542877) combined with the co...
Phase 2
Aurora, Colorado, United States and 4 other locations
to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer...
Phase 1, Phase 2
Denver, Colorado, United States and 85 other locations
the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...
Phase 2, Phase 3
Aurora, Colorado, United States and 1076 other locations
test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer...
Phase 1, Phase 2
Aurora, Colorado, United States and 21 other locations
This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.
Phase 1, Phase 2
Denver, Colorado, United States and 5 other locations
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