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This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept effi...
Phase 1
Birmingham, Alabama, United States and 10 other locations
the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...
Phase 2, Phase 3
Birmingham, Alabama, United States and 1076 other locations
The main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally ad...
Phase 1
Birmingham, Alabama, United States and 46 other locations
PRE-ISPY Phase I/II (I-SPY-P1) is an open-label, multisite platform study with multiple ongoing drug regimen arms added by protocol amendment which i...
Phase 1, Phase 2
Birmingham, Alabama, United States and 9 other locations
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with adva...
Phase 1, Phase 2
Birmingham, Alabama, United States and 231 other locations
Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab ver...
Phase 3
Birmingham, Alabama, United States and 427 other locations
a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon...
Phase 3
Birmingham, Alabama, United States and 990 other locations
2 mutations. These include tumors in the colon or rectum, the uterus and the cervix (lower part of the uterus), the breast, the bladder, and...
Phase 2
Birmingham, Alabama, United States and 55 other locations
without biological agent and monalizumab (IPH2201) with biological agent administered to participants with recurrent or metastatic colorectal cancer...
Phase 1, Phase 2
Birmingham, Alabama, United States and 48 other locations
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