This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Huntersville, NC

Revolution Medicines

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Philadelphia, PA

Dialysis and Nephrology

Clinical Research Department

Cancer Research Department

Oncology Department

Las Vegas, NV

Department of Research and Evaluation

NRG Oncology

The main aim of this study is to check for side effects and tolerability of TAK-186 (also known as MVC-101) in adults with unremovable advanced or metastatic cancer. Another aim is to characterize and evaluate the activity of TAK-186 (MVC-101).

Participants may receive treatment throughout the study for a maximum of 13 months and will be followed up at 30 days and 90 days and then every 12 weeks for up to 48 weeks after the last treatment.

A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer

Clinical Trial Center

Clinical Trials

Takeda

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon or rectal cancer.

Find clinical trials for Colon Cancer in Charlotte, NC

Related conditions:

Colon Cancer trials near Charlotte, NC, USA:

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer

S0820, Adenoma and Second Primary Prevention Trial (PACES)

Find clinical trials for Colon Cancer in .css-epvm6{white-space:nowrap;}Charlotte, NC

Related conditions:

Colon Cancer trials near Charlotte, NC, USA:

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer

S0820, Adenoma and Second Primary Prevention Trial (PACES)

Find clinical trials for Colon Cancer in Charlotte, NC