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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Westwood, Kansas, United States and 212 other locations
the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...
Phase 2, Phase 3
Kansas City, Missouri, United States and 827 other locations
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recom...
Phase 1
Kansas City, Missouri, United States and 13 other locations
plus BSC in participants with refractory metastatic colorectal cancer (mCRC). 691 participants were randomized to one of the following treat...
Phase 3
Kansas City, Missouri, United States and 152 other locations
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with adva...
Phase 1, Phase 2
Westwood, Kansas, United States and 97 other locations
light (HDWL) colonoscopy for screening or surveillance of colorectal Cancer (CRC).Eligible subjects who meet the study inclusion/exclusion c...
Kansas City, Missouri, United States and 4 other locations
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors an...
Phase 2
Saint Joseph, Missouri, United States and 79 other locations
a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon...
Phase 3
Kansas City, Kansas, United States and 989 other locations
tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer, or Stage II (high risk)/Stage III colon cancer....
Phase 2
Westwood, Kansas, United States and 112 other locations
The primary objective of the Phase 2 portion of the study is to characterize the clinical activity of maintenance therapy with GRT-C901/GRT-R902 (pat...
Phase 2, Phase 3
Fairway, Kansas, United States and 42 other locations
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