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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Westwood, Kansas, United States and 250 other locations
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor...
Phase 2, Phase 3
Kansas City, Missouri, United States and 878 other locations
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose ...
Phase 1
Kansas City, Missouri, United States and 14 other locations
plus BSC in participants with refractory metastatic colorectal cancer (mCRC). 691 participants were randomized to one of the following treat...
Phase 3
Kansas City, Missouri, United States and 152 other locations
evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors...
Phase 1, Phase 2
Westwood, Kansas, United States and 219 other locations
of RO7198457 versus watchful waiting in patients with circulating tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer...
Phase 2
Westwood, Kansas, United States and 112 other locations
a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon...
Phase 3
Kansas City, Kansas, United States and 989 other locations
versus a fluoropyrimidine/bevacizumab alone as assessed by molecular response which is based on changes in circulating tumor (ct)DNA. The...
Phase 2, Phase 3
Fairway, Kansas, United States and 42 other locations
and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers...
Phase 2
Kansas City, Kansas, United States and 65 other locations
diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic di...
Phase 2
Westwood, Kansas, United States and 7 other locations
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