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FRONTIER Study is a prospective, interventional, single-arm, multi-center, study to assess the safety and technical feasibility of TheraSphere GBM...
Early Phase 1
Chicago, Illinois, United States and 4 other locations
The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM...
Phase 3
Chicago, Illinois, United States and 85 other locations
This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblastoma (GBM) or other recurrent glioma...
Phase 2
Chicago, Illinois, United States and 80 other locations
The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by a chemical change)....
Phase 3
Chicago, Illinois, United States and 122 other locations
are also impermeable to the passage of therapeutic molecules from the blood to the brain. The development of effective treatments against glioblastoma...
Phase 3
Chicago, Illinois, United States and 12 other locations
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...
Chicago, Illinois, United States and 132 other locations
Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the bl...
Phase 1, Phase 2
Chicago, Illinois, United States
This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...
Phase 1, Phase 2
Warrenville, Illinois, United States and 11 other locations
This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an...
Phase 1, Phase 2
Chicago, Illinois, United States and 11 other locations
progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM) can be improved by the addition of i...
Phase 3
Maywood, Illinois, United States and 18 other locations
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