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Find clinical trials for Glioblastoma (GBM) in London, England

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Related conditions:

Glioblastoma
Recurrence
Glioma
Brain Cancer
Astrocytoma
Cancer
Gliosarcoma

Glioblastoma (GBM) trials near London, England, GBR:

5G-EMERALD: Amivantamab in Malignant Brain Tumours

The purpose of this clinical trial is to evaluate the safety and tolerability of amivantamab and to determine the preliminary antitumour activity of...

Enrolling
Glioblastoma Multiform (Grade IV Astrocytoma)
Glioblastoma Multiforme (GBM)
Drug: Amivantamab

Phase 1

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom and 1 other location

a treatment in any biomarker arm has met the "GO" decision (≥3 successes/12 patients) for relapsed GBM in Phase 1b, that arm can progress t...

Enrolling
Glioblastoma Multiform (Grade IV Astrocytoma)
Glioblastoma Multiforme (GBM)
Drug: Avutometinib
Drug: Defactinib

Phase 1, Phase 2

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom and 2 other locations

placebo-controlled, randomised trial to compare the cannabinoid Nabiximols with placebo in patients with recurrent MGMT methylated glioblastoma...

Enrolling
Glioblastoma
Brain Tumor, Recurrent
Drug: Nabiximols-matched placebo
Drug: Nabiximols

Phase 2

University of Birmingham

London, United Kingdom and 20 other locations

This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblastoma (GBM) or other recurrent glioma...

Active, not recruiting
Glioblastoma
Adult-type Diffuse Gliomas
Drug: Pemigatinib

Phase 2

Incyte
Incyte

London, United Kingdom and 80 other locations

The purpose of this first-in-human (FIH) study of \[177Lu\]-NeoB is to characterize the safety, tolerability, pharmacokinetics (PK) as well as the di...

Enrolling
Neoplasms
Drug: [68Ga]-NeoB
Drug: LCZ696

Phase 1, Phase 2

Advanced Accelerator Applications

Cambridge, United Kingdom and 13 other locations

To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...

Active, not recruiting
Glioblastoma Multiforme
Device: Optune®
NovoCure
NovoCure

London, United Kingdom and 132 other locations

This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...

Active, not recruiting
Glioblastoma
Glioblastoma Multiforme
Drug: ST101
Drug: Temozolomide

Phase 1, Phase 2

Sapience Therapeutics

London, United Kingdom and 10 other locations

This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the firs...

Enrolling
Recurrent Glioblastoma Multiforme
Primary Glioblastoma Multiforme
Radiation: Radiation Therapy
Drug: AZD1390

Phase 1

AstraZeneca
AstraZeneca

London, United Kingdom and 11 other locations

progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM) can be improved by the addition of i...

Active, not recruiting
Glioblastoma
Procedure: Standard surgery
Drug: Temozolomide

Phase 3

Universitätsmedizin Mannheim

London, United Kingdom and 18 other locations

The proposed Phase IIB/III randomized, double-blind, placebo-controlled trial in subjects with newly diagnosed primary glioblastoma multifor...

Active, not recruiting
Glioblastoma Multiforme
Primary Glioblastoma
Drug: TMZ
Drug: LAM561

Phase 2, Phase 3

Laminar Pharma

London, United Kingdom and 21 other locations

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