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Find clinical trials for Glioblastoma (GBM) in London, England

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Related conditions:

Glioblastoma
Brain Cancer
Glioma
Cancer
Recurrence
Astrocytoma
Gliosarcoma

Glioblastoma (GBM) trials near London, England, GBR:

5G-EMERALD: Amivantamab in Malignant Brain Tumours

The purpose of this clinical trial is to evaluate the safety and tolerability of amivantamab and to determine the preliminary antitumour activity of...

Active, not recruiting
Glioblastoma Multiform (Grade IV Astrocytoma)
Glioblastoma Multiforme (GBM)
Drug: Amivantamab

Phase 1

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom and 1 other location

The purpose of this clinical trial is to evaluate the safety and tolerability of paxalisib in combination with temozolomide and to determine the prel...

Enrolling
Glioblastoma Multiforme (GBM)
Malignant Primary Gliomas
Drug: Temozolomide capsule
Drug: Paxalisib

Phase 1, Phase 2

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom

a treatment in any biomarker arm has met the "GO" decision (≥3 successes/12 patients) for relapsed GBM in Phase 1b, that arm can progress t...

Enrolling
Glioblastoma Multiform (Grade IV Astrocytoma)
Glioblastoma Multiforme (GBM)
Drug: Avutometinib
Drug: Defactinib

Phase 1, Phase 2

Institute of Cancer Research, United Kingdom

Sutton, United Kingdom and 2 other locations

placebo-controlled, randomised trial to compare the cannabinoid Nabiximols with placebo in patients with recurrent MGMT methylated glioblastoma...

Active, not recruiting
Glioblastoma
Brain Tumor, Recurrent
Drug: Nabiximols-matched placebo
Drug: Nabiximols

Phase 2

University of Birmingham

London, United Kingdom and 16 other locations

Optune® together with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the stud...

Enrolling
Glioblastoma
Drug: Temozolomide
Drug: Placebo

Phase 3

NovoCure
NovoCure

London, Greater London, United Kingdom and 101 other locations

(TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main question it aims to ans...

Active, not recruiting
Glioblastoma
GBM
Drug: Niraparib
Drug: Temozolomide

Phase 3

Ivy Brain Tumor Center

London, United Kingdom and 94 other locations

This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...

Active, not recruiting
Glioblastoma
Glioblastoma Multiforme
Drug: ST101
Drug: Temozolomide

Phase 1, Phase 2

Sapience Therapeutics

London, United Kingdom and 10 other locations

The study treatment, BAY 3713372, is under development to treat MTAP (methylthioadenosine phosphorylase)-deleted solid tumors. It is thought to work...

Enrolling
MTAP-deleted Solid Tumors
Drug: BAY 3713372

Phase 1, Phase 2

Bayer
Bayer

Sutton, Surrey, United Kingdom and 62 other locations

This is a single centre, proof-of-concept phase I trial of atezolizumab in combination with ipatasertib. There are two parts to this study, the dose...

Active, not recruiting
Glioblastoma Multiforme
Solid Tumor
Drug: ipatasertib
Drug: Atezolizumab

Phase 1, Phase 2

Institute of Cancer Research, United Kingdom

Sutton, Surrey, United Kingdom

Butterfly glioblastomas (bGBM), defined as tumours crossing the midline to involve hemispheres bilaterally, have a dismal prognosis with a m...

Enrolling
GBM
Brain Tumours
Procedure: surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
King's College Hospital NHS Trust

London, United Kingdom

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