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The purpose of this clinical trial is to evaluate the safety and tolerability of amivantamab and to determine the preliminary antitumour activity of...
Phase 1
Sutton, United Kingdom and 1 other location
a treatment in any biomarker arm has met the "GO" decision (≥3 successes/12 patients) for relapsed GBM in Phase 1b, that arm can progress t...
Phase 1, Phase 2
Sutton, United Kingdom and 2 other locations
placebo-controlled, randomised trial to compare the cannabinoid Nabiximols with placebo in patients with recurrent MGMT methylated glioblastoma...
Phase 2
London, United Kingdom and 20 other locations
The purpose of this first-in-human (FIH) study of \[177Lu\]-NeoB is to characterize the safety, tolerability, pharmacokinetics (PK) as well as the di...
Phase 1, Phase 2
Cambridge, United Kingdom and 13 other locations
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...
London, United Kingdom and 132 other locations
This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...
Phase 1, Phase 2
London, United Kingdom and 10 other locations
This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the firs...
Phase 1
London, United Kingdom and 11 other locations
progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM) can be improved by the addition of i...
Phase 3
London, United Kingdom and 18 other locations
The proposed Phase IIB/III randomized, double-blind, placebo-controlled trial in subjects with newly diagnosed primary glioblastoma multifor...
Phase 2, Phase 3
London, United Kingdom and 21 other locations
To assess:* efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification...
Phase 2
London, United Kingdom and 90 other locations
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