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Find clinical trials for Heart Disease in Charlotte, NC

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Related conditions:

Heart Diseases
Coronary Artery Disease
Cardiovascular Diseases
Myocardial Ischemia
Heart Failure
Coronary Disease
Hypertension

Heart Disease trials near Charlotte, NC, USA:

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2 (Re-PHIRE)

is intended to assess the ability of AZD3427 to reduce pulmonary vascular resistance (PVR) after 24 weeks of treatment in participants with heart...

Enrolling
Heart Failure
Pulmonary Hypertension (World Health Organization Group 2)
Drug: AZD3427
Drug: Placebo

Phase 2

AstraZeneca
AstraZeneca

Rock Hill, South Carolina, United States and 63 other locations

EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Dr...

Enrolling
Transplant; Failure, Heart
Congenital Heart Disease
Device: EXCOR Active Driving System for Pediatric VAD
Berlin Heart

Charlotte, North Carolina, United States and 10 other locations

Harmony TPV Post-Approval Study

The purpose of this study is to characterize the functionality of transcatheter implantation of the Medtronic Harmony Transcatheter Pulmonary Valve (...

Enrolling
Congenital Heart Disease
Tetrology of Fallot
Device: Harmony TPV System
Covidien
Covidien

Charlotte, North Carolina, United States and 18 other locations

EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis

This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3/SAPIEN 3 Ultra Transcatheter Heart Valve (THV) compared with c...

Active, not recruiting
Heart Diseases
Aortic Stenosis, Severe
Device: Edwards SAPIEN 3 / SAPIEN 3 Ultra THV
Edwards Lifesciences
Edwards Lifesciences

Charlotte, North Carolina, United States and 76 other locations

PARTNER 3 Trial - Aortic Valve-in-Valve

This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failin...

Enrolling
Aortic Stenosis, Severe
Aortic Stenosis
Device: Edwards SAPIEN 3/SAPIEN 3 Ultra THV
Edwards Lifesciences
Edwards Lifesciences

Charlotte, North Carolina, United States and 50 other locations

PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis (P3)

To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) in patients with severe, calcific aortic s...

Active, not recruiting
Aortic Stenosis
Device: SAPIEN 3 THV
Procedure: SAVR
Edwards Lifesciences
Edwards Lifesciences

Charlotte, North Carolina, United States and 76 other locations

Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function (PROTECT IV)

2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart...

Enrolling
Coronary Artery Disease
Left Ventricular Dysfunction
Device: Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®
Device: IABP Intra-aortic balloon pump
Abiomed
Abiomed

Charlotte, North Carolina, United States and 122 other locations

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart F...

Active, not recruiting
Heart Failure
Other: Placebo
Drug: Finerenone (BAY94-8862)

Phase 3

Bayer
Bayer

Lancaster, South Carolina, United States and 663 other locations

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardio...

Enrolling
Cardiovascular Disease
Drug: Semaglutide
Drug: Cagrilintide

Phase 3

Novo Nordisk
Novo Nordisk

Statesville, North Carolina, United States and 521 other locations

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV)

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults wi...

Active, not recruiting
Coronary Heart Disease (CHD)
Drug: Evolocumab
Drug: Placebo

Phase 3

Amgen
Amgen

Charlotte, North Carolina, United States and 851 other locations

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