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Find clinical trials for Kidney Disease in Louisville, KY

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Related conditions:

Kidney Diseases
Chronic Renal Insufficiency
Chronic Kidney Failure
IGA Glomerulonephritis
Renal Cell Carcinoma
Renal Insufficiency
Carcinoma

Kidney Disease trials near Louisville, KY, USA:

Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects with Hypertension and Chronic Kidney Disease (CKD) with Albuminuria

This is a randomized, double-blind (DB), placebo controlled, crossover study with a two-period, two-sequence (2x2) design evaluating the efficacy and...

Enrolling
Chronic Kidney Disease
Drug: Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QD
Drug: Placebo QD + SGLT2i QD, Washout, Lorundrostat 25mg+SGLT2i QD

Phase 2

Mineralys Therapeutics

Louisville, Kentucky, United States and 43 other locations

Locations recently updated

The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the cl...

Enrolling
Chronic Kidney Disease
Cardiac Disease
Drug: Placebo
Drug: Ravulizumab

Phase 3

Alexion Pharmaceuticals
Alexion Pharmaceuticals

Louisville, Kentucky, United States and 191 other locations

(for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.Parti...

Enrolling
Chronic Kidney Disease
Inflammation
Drug: Placebo (Ziltivekimab B)
Drug: Placebo (Ziltivekimab C)

Phase 3

Novo Nordisk
Novo Nordisk

Louisville, Kentucky, United States and 950 other locations

of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/ ...

Enrolling
Overweight and Obesity
Drug: Retatrutide
Drug: Placebo

Phase 3

Lilly
Lilly

Louisville, Kentucky, United States and 707 other locations

The ALIGN Study is a phase 3, double-blind, placebo-controlled study to compare the efficacy and safety of atrasentan to placebo in patients with IgA...

Active, not recruiting
Immunoglobulin A Nephropathy
IgA Nephropathy
Drug: Placebo
Drug: Atrasentan

Phase 3

Chinook Therapeutics

Louisville, Kentucky, United States and 135 other locations

The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen implant (SeCI; Sirogen), a single dose prophylactic treatmen...

Active, not recruiting
Chronic Kidney Failure
End Stage Renal Disease
Drug: Sirolimus

Phase 3

Vascular Therapies, Inc.

Louisville, Kentucky, United States and 21 other locations

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabete...

Active, not recruiting
Chronic Kidney Disease
Cardiovascular Diseases
Drug: Orforglipron
Drug: Insulin Glargine

Phase 3

Lilly
Lilly

Louisville, Kentucky, United States and 395 other locations

The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and...

Enrolling
Immunoglobulin A Nephropathy
Lupus Nephritis
Drug: Placebo
Drug: Ravulizumab

Phase 2

Alexion Pharmaceuticals
Alexion Pharmaceuticals

Louisville, Kentucky, United States and 104 other locations

Locations recently updated

To determine the long-term (approximately 2 years) nephroprotective potential of treatment with sparsentan as compared to an angiotensin receptor blo...

Active, not recruiting
Immunoglobulin A Nephropathy
Drug: irbesartan
Drug: Dapagliflozin

Phase 3

Travere Therapeutics
Travere Therapeutics

Louisville, Kentucky, United States and 161 other locations

The goal of this research study is to establish chimerism and avoid graft-versus-host disease in patients with kidney failure allow...

Active, not recruiting
Renal Failure
Biological: Enriched Hematopoietic Stem Cell Infusion

Phase 1, Phase 2

Talaris Therapeutics

Louisville, Kentucky, United States and 1 other location

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