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Find clinical trials for Kidney Disease in Louisville, KY

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Related conditions:

Kidney Diseases
Chronic Renal Insufficiency
Chronic Kidney Failure
Renal Insufficiency
IGA Glomerulonephritis
Renal Cell Carcinoma
Diabetes Mellitus

Kidney Disease trials near Louisville, KY, USA:

Efficacy and Safety of Lorundrostat Alone, and in Combination With Dapagliflozin in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria

This is a 2-part study evaluating the efficacy and safety of lorundrostat (an aldosterone synthase inhibitor [ASI]) for the treatment of hypertension...

Enrolling
Chronic Kidney Disease
Drug: Part A - Lorundrostat QD + Dapaglifozin QD
Drug: Part A - Lorundrostat QD

Phase 2

Mineralys Therapeutics

Louisville, Kentucky, United States and 22 other locations

to placebo in reducing the intensity of itch in advanced chronic kidney disease (CKD) patients with moderate-to-severe pruritus. Th...

Enrolling
Chronic Kidney Diseases
Pruritus
Drug: Difelikefalin 1 mg Oral Tablet
Drug: Placebo Oral Tablet

Phase 3

Cara Therapeutics
Cara Therapeutics

Louisville, Kentucky, United States and 82 other locations

The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the cl...

Enrolling
Chronic Kidney Disease
Cardiac Disease
Drug: Placebo
Drug: Ravulizumab

Phase 3

Alexion Pharmaceuticals
Alexion Pharmaceuticals

Louisville, Kentucky, United States and 159 other locations

(for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.Parti...

Enrolling
Chronic Kidney Disease
Inflammation
Drug: Ziltivekimab C
Drug: Placebo (Ziltivekimab B)

Phase 3

Novo Nordisk
Novo Nordisk

Louisville, Kentucky, United States and 943 other locations

The ALIGN Study is a phase 3, double-blind, placebo-controlled study to compare the efficacy and safety of atrasentan to placebo in patients with IgA...

Active, not recruiting
Immunoglobulin A Nephropathy
IgA Nephropathy
Drug: Placebo
Drug: Atrasentan

Phase 3

Chinook Therapeutics

Louisville, Kentucky, United States and 166 other locations

The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen implant (SeCI; Sirogen), a single dose prophylactic treatmen...

Enrolling
Chronic Kidney Failure
End Stage Renal Disease
Drug: Sirolimus

Phase 3

Vascular Therapies, Inc.

Louisville, Kentucky, United States and 22 other locations

This is a Phase II trial assessing the safety and preliminary efficacy of daily APL-2 subcutaneous infusion administered for 16 weeks with a 6 month...

Active, not recruiting
Dense Deposit Disease
Membranous Nephropathy
Drug: APL-2

Phase 2

Apellis Pharmaceuticals

Jeffersonville, Indiana, United States and 16 other locations

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabete...

Enrolling
Chronic Kidney Disease
Cardiovascular Diseases
Drug: Orforglipron
Drug: Insulin Glargine

Phase 3

Lilly
Lilly

Louisville, Kentucky, United States and 390 other locations

The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and...

Enrolling
Immunoglobulin A Nephropathy
Lupus Nephritis
Drug: Placebo
Drug: Ravulizumab

Phase 2

Alexion Pharmaceuticals
Alexion Pharmaceuticals

Louisville, Kentucky, United States and 80 other locations

To determine the long-term (approximately 2 years) nephroprotective potential of treatment with sparsentan as compared to an angiotensin receptor blo...

Active, not recruiting
Immunoglobulin A Nephropathy
Drug: Dapagliflozin
Drug: irbesartan

Phase 3

Travere Therapeutics
Travere Therapeutics

Louisville, Kentucky, United States and 161 other locations

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