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Find clinical trials for Leukemia in Charlotte, NC

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Related conditions:

Myeloid Leukemia
Acute Myeloid Leukemia
Lymphoid Leukemia
B-Cell Chronic Lymphocytic Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphoma
Myelodysplastic Syndromes

Leukemia trials near Charlotte, NC, USA:

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

The overarching objective of this study is to use novel precision medicine strategies based on inherited and acquired leukemia-specific geno...

Active, not recruiting
Acute Lymphoblastic Leukemia
Acute Lymphoblastic Lymphoma
Drug: Asparaginase Erwinia chrysanthemi (recombinant)-rywn
Drug: Thioguanine

Phase 2, Phase 3

St. Jude Children's Research Hospital
St. Jude Children's Research Hospital

Charlotte, North Carolina, United States and 7 other locations

chemotherapy in induction-eligible patients with acute myeloid leukemia.This study involves the following:* Venetoclax and azacitidine (inve...

Enrolling
Acute Myeloid Leukemia
Drug: Venetoclax
Drug: Azacitidine

Phase 2

Mass General Brigham
Mass General Brigham

Charlotte, North Carolina, United States and 8 other locations

chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optimize the dose of study drug (rux...

Active, not recruiting
Leukemia
Drug: Methotrexate
Drug: Thioguanine

Phase 2

Incyte
Incyte

Charlotte, North Carolina, United States and 110 other locations

of a type of immunotherapy called blinatumomab to clear persistent leukemia. Blinatumomab targets CD19 which is located on the leukemia...

Enrolling
Lymphoblastic Leukemia
Drug: Methotrexate
Drug: Ziftomenib

Phase 1, Phase 2

Tanja Andrea Gruber

Charlotte, North Carolina, United States and 24 other locations

New

To assess the efficacy and safety of pirtobrutinib in participants with CLL/SLL who have progressed on first-line treatment with acalabrutinib.

Begins enrollment in 4 months
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Drug: Acalabrutinib
Drug: Pirtobrutinib

Phase 2

AstraZeneca
AstraZeneca

Charlotte, North Carolina, United States and 12 other locations

Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess retr...

Enrolling
Chronic Lymphocytic Leukemia (CLL)
Drug: Venetoclax
Drug: Obinutuzumab

Phase 2

AbbVie
AbbVie

Charlotte, North Carolina, United States and 51 other locations

A study of acalabrutinib plus venetoclax (AV) versus venetoclax plus obinutuzumab (VO) in previously untreated chronic lymphocytic leukemia ...

Active, not recruiting
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Drug: Venetoclax
Drug: Obinutuzumab

Phase 3

AstraZeneca
AstraZeneca

Charlotte, North Carolina, United States and 37 other locations

Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The purpose of this study is to assess how wel...

Enrolling
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Drug: Obinutuzumab
Drug: ABBV-453

Phase 1

AbbVie
AbbVie

Charlotte, North Carolina, United States and 17 other locations

previously treated or untreated with high risk factor acute myeloid leukemia (AML). Venetoclax and azacitidine are front-line therapy for su...

Enrolling
Acute Myeloid Leukemia, Adult
Drug: ADI-PEG 20

Phase 1

Polaris Group

Charlotte, North Carolina, United States and 3 other locations

The purpose of this study is to determine the recommended Phase 2 dose (RP2D) candidate(s) of bleximenib in combination with AML directed therapies (...

Enrolling
Leukemia, Myeloid, Acute
Drug: Cytarabine
Drug: Bleximenib

Phase 1

Janssen (J&J Innovative Medicine)
Janssen (J&J Innovative Medicine)

Charlotte, North Carolina, United States and 31 other locations

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