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Find clinical trials for Leukemia in Charlotte, NC

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Related conditions:

Myeloid Leukemia
Acute Myeloid Leukemia
Lymphoid Leukemia
B-Cell Chronic Lymphocytic Leukemia
Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myelodysplastic Syndromes

Leukemia trials near Charlotte, NC, USA:

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

The overarching objective of this study is to use novel precision medicine strategies based on inherited and acquired leukemia-specific geno...

Active, not recruiting
Acute Lymphoblastic Leukemia
Acute Lymphoblastic Lymphoma
Drug: Asparaginase Erwinia chrysanthemi (recombinant)-rywn
Drug: Thioguanine

Phase 2, Phase 3

St. Jude Children's Research Hospital
St. Jude Children's Research Hospital

Charlotte, North Carolina, United States and 7 other locations

chemotherapy in induction-eligible patients with acute myeloid leukemia.This study involves the following:* Venetoclax and azacitidine (inve...

Enrolling
Acute Myeloid Leukemia
Drug: Venetoclax
Drug: Azacitidine

Phase 2

Mass General Brigham
Mass General Brigham

Charlotte, North Carolina, United States and 8 other locations

chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optimize the dose of study drug (rux...

Active, not recruiting
Leukemia
Drug: Methotrexate
Drug: Thioguanine

Phase 2

Incyte
Incyte

Charlotte, North Carolina, United States and 110 other locations

The purpose of this study is to determine the recommended Phase 2 dose (RP2D) candidate(s) of JNJ-75276617 in combination with AML directed therapies...

Enrolling
Leukemia, Myeloid, Acute
Drug: Azacitidine (AZA)
Drug: Cytarabine

Phase 1

Janssen (J&J Innovative Medicine)
Janssen (J&J Innovative Medicine)

Charlotte, North Carolina, United States and 30 other locations

Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess retr...

Enrolling
Chronic Lymphocytic Leukemia (CLL)
Drug: Venetoclax
Drug: Obinutuzumab

Phase 2

AbbVie
AbbVie

Charlotte, North Carolina, United States and 48 other locations

A study of acalabrutinib plus venetoclax (AV) versus venetoclax plus obinutuzumab (VO) in previously untreated chronic lymphocytic leukemia ...

Active, not recruiting
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Drug: Venetoclax
Drug: Obinutuzumab

Phase 3

AstraZeneca
AstraZeneca

Charlotte, North Carolina, United States and 40 other locations

(R/R) lymphoma* multiple myeloma* newly diagnosed acute myeloid leukemia (AML).This trial will be conducted in the outpatient setting in 2 p...

Active, not recruiting
Acute Myeloid Leukemia
Multiple Myeloma
Drug: Dexamethasone
Drug: Venetoclax

Phase 1

Pfizer
Pfizer

Charlotte, North Carolina, United States and 61 other locations

previously treated or untreated with high risk factor acute myeloid leukemia (AML). Venetoclax and azacitidine are front-line therapy for su...

Enrolling
Acute Myeloid Leukemia, Adult
Drug: ADI-PEG 20

Phase 1

Polaris Group

Charlotte, North Carolina, United States and 2 other locations

and young adult participants with relapsed/refractory acute leukemia harboring histone-lysine N-methyltransferase 2A1 (\[KMT2A1\], nucleopho...

Begins enrollment in a year or more
Acute Leukemia of Ambiguous Lineage
Acute Leukemias
Drug: Cytarabine
Drug: Dexamethasone

Phase 1

Janssen (J&J Innovative Medicine)
Janssen (J&J Innovative Medicine)

Charlotte, North Carolina, United States and 11 other locations

This is a Phase 1-2, multicenter, international, single-arm, open-label study designed to identify a recommended dose of bosutinib administered orall...

Active, not recruiting
Blastic Phase Chronic Myelogenous Leukemia
Chronic Phase Chronic Myelogenous Leukemia
Drug: Bosutinib

Phase 1, Phase 2

Children's Oncology Group

Charlotte, North Carolina, United States and 44 other locations

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